TY - JOUR
T1 - Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea
AU - Serrano-Pariente, J.
AU - Plaza, V.
AU - Soriano, J. B.
AU - Mayos, M.
AU - López-Viña, A.
AU - Picado, C.
AU - Vigil, L.
AU - Sogo-Sagardía, Ana
AU - Crespo-Lessmann, Astrid
AU - Fortuna-Gutiérrez, Ana M.
AU - González-Gutiérrez, M. Victoria
AU - Ortega-Castillo, M. Pilar
AU - Bardagí-Forns, Santiago
AU - Abeijón-Insua, Benedicta
AU - Somoza-González, María
AU - González-Barcala, Francisco Javier
AU - García-Rivero, Juan Luis
AU - González-Martínez, Mónica
AU - Sacristán-Bou, Lirios
AU - Trisán-Alonso, Andrea
AU - Martínez-Moragón, Eva
AU - Almonacid-Sánchez, Carlos
AU - Cisneros-Serrano, Carolina
AU - Mayoralas-Alises, Sagrario
AU - Figueroa-Cézar, Milagros
PY - 2017/5/1
Y1 - 2017/5/1
N2 - © 2016 The Authors. Allergy published by John Wiley & Sons Ltd. Background: Continuous positive airway pressure (CPAP) in asthma patients with concomitant obstructive sleep apnea syndrome (OSAS) seems to have a favorable impact on asthma, but data are inconsistent due to methodological limitations of previous studies. Methods: Prospective, multicenter study. We examined asthma outcomes after 6 months of CPAP in 99 adult asthma patients (mean age 57 years) with OSAS (respiratory disturbance index ≥20). Asthma control and quality of life were assessed with the Asthma Control Questionnaire (ACQ) and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), respectively. Data were analyzed by intention-to-treat basis. Results: The mean ± SD score of the ACQ decreased from 1.39 ± 0.91 at baseline to 1.0 ± 0.78 at 6 months (P = 0.003), the percentage of patients with uncontrolled asthma from 41.4% to 17.2% (P = 0.006), and the percentage of patients with asthma attacks in the 6 months before and after treatment from 35.4% to 17.2% (P = 0.015). The score of the mAQLQ increased from 5.12 ± 1.38 to 5.63 ± 1.17 (P = 0.009). There were also significant improvements in symptoms of gastroesophageal reflux and rhinitis, bronchial reversibility, and exhaled nitric oxide values (all P < 0.05). No significant changes were observed in drug therapy for asthma or their comorbidities nor in the patients’ weight. Conclusions: Asthma control (both actual and future risk), quality of life, and lung function improved after starting continuous positive airway pressure in asthmatics with moderate to severe obstructive sleep apnea syndrome.
AB - © 2016 The Authors. Allergy published by John Wiley & Sons Ltd. Background: Continuous positive airway pressure (CPAP) in asthma patients with concomitant obstructive sleep apnea syndrome (OSAS) seems to have a favorable impact on asthma, but data are inconsistent due to methodological limitations of previous studies. Methods: Prospective, multicenter study. We examined asthma outcomes after 6 months of CPAP in 99 adult asthma patients (mean age 57 years) with OSAS (respiratory disturbance index ≥20). Asthma control and quality of life were assessed with the Asthma Control Questionnaire (ACQ) and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), respectively. Data were analyzed by intention-to-treat basis. Results: The mean ± SD score of the ACQ decreased from 1.39 ± 0.91 at baseline to 1.0 ± 0.78 at 6 months (P = 0.003), the percentage of patients with uncontrolled asthma from 41.4% to 17.2% (P = 0.006), and the percentage of patients with asthma attacks in the 6 months before and after treatment from 35.4% to 17.2% (P = 0.015). The score of the mAQLQ increased from 5.12 ± 1.38 to 5.63 ± 1.17 (P = 0.009). There were also significant improvements in symptoms of gastroesophageal reflux and rhinitis, bronchial reversibility, and exhaled nitric oxide values (all P < 0.05). No significant changes were observed in drug therapy for asthma or their comorbidities nor in the patients’ weight. Conclusions: Asthma control (both actual and future risk), quality of life, and lung function improved after starting continuous positive airway pressure in asthmatics with moderate to severe obstructive sleep apnea syndrome.
KW - asthma
KW - bronchial hyperreactivity
KW - continuous positive airway pressure
KW - obstructive sleep apnea syndrome
KW - quality of life
U2 - https://doi.org/10.1111/all.13070
DO - https://doi.org/10.1111/all.13070
M3 - Article
VL - 72
SP - 802
EP - 812
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 5
ER -