Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

Anna Hernández-Rubio, Arantza Sanvisens, Lucía Barbier-Torres, Rafael Blanes, Laia Miquel, Marta Torrens, Gabriel Rubio, Ferran Bolao, Paola Zuluaga, Daniel Fuster, Fernando Rodríguez de Fonseca, Magí Farré, Robert Muga*, Coh RTA Study, Coordinating Center, Esther Papasseit, Clara Pérez-Mañá, Lourdes Poyatos, Nuria García-Marchena, Enric AbellíAntonio Short, Catalina Moranta, Ana Sion, Lluisa Ortega, Pol Bruguera, Elsa Caballeria, Ana Messeguer, Francina Fonseca, Juan Ignacio Mestre-Pinto, María Alías, Fernando Dinamarca, Francisco Javier Pavón-Morón, Pedro Araos, María Flores-López, Antonia Serrano, Miguel Marcos, Candelaria Martín, Onán Pérez-Hernández, Jorge Manzanares, Lucía Illescas

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review


INTRODUCTION: Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD.

PATIENTS AND METHODS: Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.

RESULTS: 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41-56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3-23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0-26.2) were the only factors associated with hypoMg.

CONCLUSIONS: Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.

Original languageEnglish
Article number109822
Pages (from-to)109822
Number of pages7
JournalDrug Alcohol Depend
Publication statusPublished - 1 Apr 2023


  • Alcohol use disorder
  • Electrolyte disturbances
  • Magnesium deficiency
  • Oxidative stress
  • Liver Cirrhosis/complications
  • Cross-Sectional Studies
  • Humans
  • Middle Aged
  • Male
  • Alcohol Drinking
  • Alcoholism/epidemiology
  • Adult
  • Female
  • Magnesium


Dive into the research topics of 'Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder'. Together they form a unique fingerprint.

Cite this