Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

Anna Hernández-Rubio; Arantza Sanvisens; Lucía Barbier-Torres; Rafael Blanes; Laia Miquel; Marta Torrens; Gabriel Rubio; Ferran Bolao; Paola Zuluaga; Daniel Fuster; Fernando Rodríguez de Fonseca; Magí Farré; Robert Muga; Esther Papasseit; Clara Pérez-Mañá; Lourdes Poyatos; Nuria García-Marchena; Enric Abellí; Antonio Short; Catalina Moranta; Ana Sion; Lluisa Ortega; Pol Bruguera; Elsa Caballeria; Ana Messeguer; Francina Fonseca; Juan Ignacio Mestre-Pinto; María Alías; Fernando Dinamarca; Francisco Javier Pavón-Morón; Pedro Araos; María Flores-López; Antonia Serrano; Miguel Marcos; Candelaria Martín; Onán Pérez-Hernández; Jorge Manzanares; Lucía Illescas

doi:10.1016/j.drugalcdep.2023.109822

Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

Anna Hernández-Rubio, Arantza Sanvisens, Lucía Barbier-Torres, Rafael Blanes, Laia Miquel, Marta Torrens, Gabriel Rubio, Ferran Bolao, Paola Zuluaga, Daniel Fuster, Fernando Rodríguez de Fonseca, Magí Farré, Robert Muga^*, Esther Papasseit, Clara Pérez-Mañá, Lourdes Poyatos, Nuria García-Marchena, Enric Abellí, Antonio Short, Catalina MorantaAna Sion, Lluisa Ortega, Pol Bruguera, Elsa Caballeria, Ana Messeguer, Francina Fonseca, Juan Ignacio Mestre-Pinto, María Alías, Fernando Dinamarca, Francisco Javier Pavón-Morón, Pedro Araos, María Flores-López, Antonia Serrano, Miguel Marcos, Candelaria Martín, Onán Pérez-Hernández, Jorge Manzanares, Lucía Illescas

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

INTRODUCTION: Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD.

PATIENTS AND METHODS: Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.

RESULTS: 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41-56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3-23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0-26.2) were the only factors associated with hypoMg.

CONCLUSIONS: Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.

Original language	English
Article number	109822
Pages (from-to)	109822
Number of pages	7
Journal	Drug Alcohol Depend
Volume	245
DOIs	https://doi.org/10.1016/j.drugalcdep.2023.109822
Publication status	Published - 1 Apr 2023

Keywords

Alcohol use disorder
Electrolyte disturbances
Magnesium deficiency
Oxidative stress
Liver Cirrhosis/complications
Cross-Sectional Studies
Humans
Middle Aged
Male
Alcohol Drinking
Alcoholism/epidemiology
Adult
Female
Magnesium

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Hernández-Rubio, A., Sanvisens, A., Barbier-Torres, L., Blanes, R., Miquel, L., Torrens, M., Rubio, G., Bolao, F., Zuluaga, P., Fuster, D., Rodríguez de Fonseca, F., Farré, M., Muga, R., Papasseit, E., Pérez-Mañá, C., Poyatos, L., García-Marchena, N., Abellí, E., Short, A., ... Illescas, L. (2023). Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder. Drug Alcohol Depend, 245, 109822. Article 109822. https://doi.org/10.1016/j.drugalcdep.2023.109822

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title = "Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder",

abstract = "INTRODUCTION: Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD.PATIENTS AND METHODS: Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.RESULTS: 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41-56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3-23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0-26.2) were the only factors associated with hypoMg.CONCLUSIONS: Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.",

keywords = "Alcohol use disorder, Electrolyte disturbances, Magnesium deficiency, Oxidative stress, Liver Cirrhosis/complications, Cross-Sectional Studies, Humans, Middle Aged, Male, Alcohol Drinking, Alcoholism/epidemiology, Adult, Female, Magnesium",

author = "Anna Hern{\'a}ndez-Rubio and Arantza Sanvisens and Luc{\'i}a Barbier-Torres and Rafael Blanes and Laia Miquel and Marta Torrens and Gabriel Rubio and Ferran Bolao and Paola Zuluaga and Daniel Fuster and {Rodr{\'i}guez de Fonseca}, Fernando and Mag{\'i} Farr{\'e} and Robert Muga and Esther Papasseit and Clara P{\'e}rez-Ma{\~n}{\'a} and Lourdes Poyatos and Nuria Garc{\'i}a-Marchena and Enric Abell{\'i} and Antonio Short and Catalina Moranta and Ana Sion and Lluisa Ortega and Pol Bruguera and Elsa Caballeria and Ana Messeguer and Francina Fonseca and {Ignacio Mestre-Pinto}, Juan and Mar{\'i}a Al{\'i}as and Fernando Dinamarca and {Javier Pav{\'o}n-Mor{\'o}n}, Francisco and Pedro Araos and Mar{\'i}a Flores-L{\'o}pez and Antonia Serrano and Miguel Marcos and Candelaria Mart{\'i}n and On{\'a}n P{\'e}rez-Hern{\'a}ndez and Jorge Manzanares and Luc{\'i}a Illescas",

year = "2023",

month = apr,

day = "1",

doi = "10.1016/j.drugalcdep.2023.109822",

language = "English",

volume = "245",

pages = "109822",

journal = "Drug Alcohol Depend",

issn = "0376-8716",

publisher = "Elsevier Ireland Ltd",

}

Hernández-Rubio, A, Sanvisens, A, Barbier-Torres, L, Blanes, R, Miquel, L, Torrens, M, Rubio, G, Bolao, F, Zuluaga, P, Fuster, D, Rodríguez de Fonseca, F, Farré, M, Muga, R, Papasseit, E, Pérez-Mañá, C, Poyatos, L, García-Marchena, N, Abellí, E, Short, A, Moranta, C, Sion, A, Ortega, L, Bruguera, P, Caballeria, E, Messeguer, A, Fonseca, F, Ignacio Mestre-Pinto, J, Alías, M, Dinamarca, F, Javier Pavón-Morón, F, Araos, P, Flores-López, M, Serrano, A, Marcos, M, Martín, C, Pérez-Hernández, O, Manzanares, J & Illescas, L 2023, 'Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder', Drug Alcohol Depend, vol. 245, 109822, pp. 109822. https://doi.org/10.1016/j.drugalcdep.2023.109822

TY - JOUR

T1 - Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

AU - Hernández-Rubio, Anna

AU - Sanvisens, Arantza

AU - Barbier-Torres, Lucía

AU - Blanes, Rafael

AU - Miquel, Laia

AU - Torrens, Marta

AU - Rubio, Gabriel

AU - Bolao, Ferran

AU - Zuluaga, Paola

AU - Fuster, Daniel

AU - Rodríguez de Fonseca, Fernando

AU - Farré, Magí

AU - Muga, Robert

AU - Papasseit, Esther

AU - Pérez-Mañá, Clara

AU - Poyatos, Lourdes

AU - García-Marchena, Nuria

AU - Abellí, Enric

AU - Short, Antonio

AU - Moranta, Catalina

AU - Sion, Ana

AU - Ortega, Lluisa

AU - Bruguera, Pol

AU - Caballeria, Elsa

AU - Messeguer, Ana

AU - Fonseca, Francina

AU - Ignacio Mestre-Pinto, Juan

AU - Alías, María

AU - Dinamarca, Fernando

AU - Javier Pavón-Morón, Francisco

AU - Araos, Pedro

AU - Flores-López, María

AU - Serrano, Antonia

AU - Marcos, Miguel

AU - Martín, Candelaria

AU - Pérez-Hernández, Onán

AU - Manzanares, Jorge

AU - Illescas, Lucía

PY - 2023/4/1

Y1 - 2023/4/1

N2 - INTRODUCTION: Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD.PATIENTS AND METHODS: Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.RESULTS: 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41-56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3-23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0-26.2) were the only factors associated with hypoMg.CONCLUSIONS: Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.

AB - INTRODUCTION: Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD.PATIENTS AND METHODS: Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.RESULTS: 753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41-56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3-23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0-26.2) were the only factors associated with hypoMg.CONCLUSIONS: Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.

KW - Alcohol use disorder

KW - Electrolyte disturbances

KW - Magnesium deficiency

KW - Oxidative stress

KW - Liver Cirrhosis/complications

KW - Cross-Sectional Studies

KW - Humans

KW - Middle Aged

KW - Male

KW - Alcohol Drinking

KW - Alcoholism/epidemiology

KW - Adult

KW - Female

KW - Magnesium

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UR - https://www.mendeley.com/catalogue/b89da634-541a-37a9-af0a-a707a3f6e04e/

U2 - 10.1016/j.drugalcdep.2023.109822

DO - 10.1016/j.drugalcdep.2023.109822

M3 - Article

C2 - 36893509

SN - 0376-8716

VL - 245

SP - 109822

JO - Drug Alcohol Depend

JF - Drug Alcohol Depend

M1 - 109822

ER -

Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

Abstract

Keywords

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