Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making

Georgios Paslakis; Zaida Agüera; Roser Granero; Isabel Sánchez; Nadine Riesco; Susana Jiménez-Murcia; Jose C. Fernández-García; Lourdes Garrido-Sánchez; Francisco J. Tinahones; Felipe F. Casanueva; Rosa M. Baños; Cristina Botella; Ana B. Crujeiras; Rafael de la Torre; Jose M. Fernández-Real; Gema Frühbeck; Francisco J. Ortega; Amaia Rodríguez; Luís Serra-Majem; Montserrat Fitó; José M. Menchón; Fernando Fernández-Aranda

doi:10.1016/j.mce.2019.04.021

Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making

Georgios Paslakis, Zaida Agüera, Roser Granero, Isabel Sánchez, Nadine Riesco, Susana Jiménez-Murcia, Jose C. Fernández-García, Lourdes Garrido-Sánchez, Francisco J. Tinahones, Felipe F. Casanueva, Rosa M. Baños, Cristina Botella, Ana B. Crujeiras, Rafael de la Torre, Jose M. Fernández-Real, Gema Frühbeck, Francisco J. Ortega, Amaia Rodríguez, Luís Serra-Majem, Montserrat FitóJosé M. Menchón, Fernando Fernández-Aranda

Research output: Contribution to journal › Review article › Research › peer-review

10 Citations (Scopus)

Abstract

© 2019 Elsevier B.V. Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also underwent a battery of neuropsychological assessment [namely the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test (WCST), and the Stroop Color and Word Test (SCWT)]. As the main finding, we found that higher ghrelin levels predict better performance in the IGT. Ghrelin may be a putative mediator of decision-making, a finding that has not been described so far. The role of ghrelin in decision-making can only be described as speculative, as there are hardly any additional evidence-based data published up to date. Further studies are warranted.

Original language	English
Article number	110441
Journal	Molecular and Cellular Endocrinology
Volume	497
DOIs	https://doi.org/10.1016/j.mce.2019.04.021
Publication status	Published - 1 Nov 2019

Keywords

Anorexia nervosa
Appetite regulation
Decision-making
Ghrelin
Neuropsychological performance

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Paslakis, G., Agüera, Z., Granero, R., Sánchez, I., Riesco, N., Jiménez-Murcia, S., Fernández-García, J. C., Garrido-Sánchez, L., Tinahones, F. J., Casanueva, F. F., Baños, R. M., Botella, C., Crujeiras, A. B., Torre, R. D. L., Fernández-Real, J. M., Frühbeck, G., Ortega, F. J., Rodríguez, A., Serra-Majem, L., ... Fernández-Aranda, F. (2019). Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making. Molecular and Cellular Endocrinology, 497, [110441]. https://doi.org/10.1016/j.mce.2019.04.021

Paslakis, Georgios ; Agüera, Zaida ; Granero, Roser ; Sánchez, Isabel ; Riesco, Nadine ; Jiménez-Murcia, Susana ; Fernández-García, Jose C. ; Garrido-Sánchez, Lourdes ; Tinahones, Francisco J. ; Casanueva, Felipe F. ; Baños, Rosa M. ; Botella, Cristina ; Crujeiras, Ana B. ; Torre, Rafael de la ; Fernández-Real, Jose M. ; Frühbeck, Gema ; Ortega, Francisco J. ; Rodríguez, Amaia ; Serra-Majem, Luís ; Fitó, Montserrat ; Menchón, José M. ; Fernández-Aranda, Fernando. / Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making. In: Molecular and Cellular Endocrinology. 2019 ; Vol. 497.

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title = "Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making",

abstract = "{\textcopyright} 2019 Elsevier B.V. Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also underwent a battery of neuropsychological assessment [namely the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test (WCST), and the Stroop Color and Word Test (SCWT)]. As the main finding, we found that higher ghrelin levels predict better performance in the IGT. Ghrelin may be a putative mediator of decision-making, a finding that has not been described so far. The role of ghrelin in decision-making can only be described as speculative, as there are hardly any additional evidence-based data published up to date. Further studies are warranted.",

keywords = "Anorexia nervosa, Appetite regulation, Decision-making, Ghrelin, Neuropsychological performance",

author = "Georgios Paslakis and Zaida Ag{\"u}era and Roser Granero and Isabel S{\'a}nchez and Nadine Riesco and Susana Jim{\'e}nez-Murcia and Fern{\'a}ndez-Garc{\'i}a, {Jose C.} and Lourdes Garrido-S{\'a}nchez and Tinahones, {Francisco J.} and Casanueva, {Felipe F.} and Ba{\~n}os, {Rosa M.} and Cristina Botella and Crujeiras, {Ana B.} and Torre, {Rafael de la} and Fern{\'a}ndez-Real, {Jose M.} and Gema Fr{\"u}hbeck and Ortega, {Francisco J.} and Amaia Rodr{\'i}guez and Lu{\'i}s Serra-Majem and Montserrat Fit{\'o} and Mench{\'o}n, {Jos{\'e} M.} and Fernando Fern{\'a}ndez-Aranda",

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Paslakis, G, Agüera, Z, Granero, R, Sánchez, I, Riesco, N, Jiménez-Murcia, S, Fernández-García, JC, Garrido-Sánchez, L, Tinahones, FJ, Casanueva, FF, Baños, RM, Botella, C, Crujeiras, AB, Torre, RDL, Fernández-Real, JM, Frühbeck, G, Ortega, FJ, Rodríguez, A, Serra-Majem, L, Fitó, M, Menchón, JM & Fernández-Aranda, F 2019, 'Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making', Molecular and Cellular Endocrinology, vol. 497, 110441. https://doi.org/10.1016/j.mce.2019.04.021

Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making. / Paslakis, Georgios; Agüera, Zaida; Granero, Roser; Sánchez, Isabel; Riesco, Nadine; Jiménez-Murcia, Susana; Fernández-García, Jose C.; Garrido-Sánchez, Lourdes; Tinahones, Francisco J.; Casanueva, Felipe F.; Baños, Rosa M.; Botella, Cristina; Crujeiras, Ana B.; Torre, Rafael de la; Fernández-Real, Jose M.; Frühbeck, Gema; Ortega, Francisco J.; Rodríguez, Amaia; Serra-Majem, Luís; Fitó, Montserrat; Menchón, José M.; Fernández-Aranda, Fernando.

In: Molecular and Cellular Endocrinology, Vol. 497, 110441, 01.11.2019.

Research output: Contribution to journal › Review article › Research › peer-review

TY - JOUR

T1 - Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making

AU - Paslakis, Georgios

AU - Agüera, Zaida

AU - Granero, Roser

AU - Sánchez, Isabel

AU - Riesco, Nadine

AU - Jiménez-Murcia, Susana

AU - Fernández-García, Jose C.

AU - Garrido-Sánchez, Lourdes

AU - Tinahones, Francisco J.

AU - Casanueva, Felipe F.

AU - Baños, Rosa M.

AU - Botella, Cristina

AU - Crujeiras, Ana B.

AU - Torre, Rafael de la

AU - Fernández-Real, Jose M.

AU - Frühbeck, Gema

AU - Ortega, Francisco J.

AU - Rodríguez, Amaia

AU - Serra-Majem, Luís

AU - Fitó, Montserrat

AU - Menchón, José M.

AU - Fernández-Aranda, Fernando

PY - 2019/11/1

Y1 - 2019/11/1

N2 - © 2019 Elsevier B.V. Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also underwent a battery of neuropsychological assessment [namely the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test (WCST), and the Stroop Color and Word Test (SCWT)]. As the main finding, we found that higher ghrelin levels predict better performance in the IGT. Ghrelin may be a putative mediator of decision-making, a finding that has not been described so far. The role of ghrelin in decision-making can only be described as speculative, as there are hardly any additional evidence-based data published up to date. Further studies are warranted.

AB - © 2019 Elsevier B.V. Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also underwent a battery of neuropsychological assessment [namely the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test (WCST), and the Stroop Color and Word Test (SCWT)]. As the main finding, we found that higher ghrelin levels predict better performance in the IGT. Ghrelin may be a putative mediator of decision-making, a finding that has not been described so far. The role of ghrelin in decision-making can only be described as speculative, as there are hardly any additional evidence-based data published up to date. Further studies are warranted.

KW - Anorexia nervosa

KW - Appetite regulation

KW - Decision-making

KW - Ghrelin

KW - Neuropsychological performance

U2 - 10.1016/j.mce.2019.04.021

DO - 10.1016/j.mce.2019.04.021

M3 - Review article

C2 - 31121263

VL - 497

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

M1 - 110441

ER -