TY - JOUR
T1 - Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making
AU - Paslakis, Georgios
AU - Agüera, Zaida
AU - Granero, Roser
AU - Sánchez, Isabel
AU - Riesco, Nadine
AU - Jiménez-Murcia, Susana
AU - Fernández-García, Jose C.
AU - Garrido-Sánchez, Lourdes
AU - Tinahones, Francisco J.
AU - Casanueva, Felipe F.
AU - Baños, Rosa M.
AU - Botella, Cristina
AU - Crujeiras, Ana B.
AU - Torre, Rafael de la
AU - Fernández-Real, Jose M.
AU - Frühbeck, Gema
AU - Ortega, Francisco J.
AU - Rodríguez, Amaia
AU - Serra-Majem, Luís
AU - Fitó, Montserrat
AU - Menchón, José M.
AU - Fernández-Aranda, Fernando
PY - 2019/11/1
Y1 - 2019/11/1
N2 - © 2019 Elsevier B.V. Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also underwent a battery of neuropsychological assessment [namely the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test (WCST), and the Stroop Color and Word Test (SCWT)]. As the main finding, we found that higher ghrelin levels predict better performance in the IGT. Ghrelin may be a putative mediator of decision-making, a finding that has not been described so far. The role of ghrelin in decision-making can only be described as speculative, as there are hardly any additional evidence-based data published up to date. Further studies are warranted.
AB - © 2019 Elsevier B.V. Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also underwent a battery of neuropsychological assessment [namely the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test (WCST), and the Stroop Color and Word Test (SCWT)]. As the main finding, we found that higher ghrelin levels predict better performance in the IGT. Ghrelin may be a putative mediator of decision-making, a finding that has not been described so far. The role of ghrelin in decision-making can only be described as speculative, as there are hardly any additional evidence-based data published up to date. Further studies are warranted.
KW - Anorexia nervosa
KW - Appetite regulation
KW - Decision-making
KW - Ghrelin
KW - Neuropsychological performance
U2 - 10.1016/j.mce.2019.04.021
DO - 10.1016/j.mce.2019.04.021
M3 - Review article
C2 - 31121263
VL - 497
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
M1 - 110441
ER -