Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making

Georgios Paslakis, Zaida Agüera, Roser Granero, Isabel Sánchez, Nadine Riesco, Susana Jiménez-Murcia, Jose C. Fernández-García, Lourdes Garrido-Sánchez, Francisco J. Tinahones, Felipe F. Casanueva, Rosa M. Baños, Cristina Botella, Ana B. Crujeiras, Rafael de la Torre, Jose M. Fernández-Real, Gema Frühbeck, Francisco J. Ortega, Amaia Rodríguez, Luís Serra-Majem, Montserrat FitóJosé M. Menchón, Fernando Fernández-Aranda

Research output: Contribution to journalReview articleResearchpeer-review

13 Citations (Scopus)

Abstract

© 2019 Elsevier B.V. Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also underwent a battery of neuropsychological assessment [namely the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test (WCST), and the Stroop Color and Word Test (SCWT)]. As the main finding, we found that higher ghrelin levels predict better performance in the IGT. Ghrelin may be a putative mediator of decision-making, a finding that has not been described so far. The role of ghrelin in decision-making can only be described as speculative, as there are hardly any additional evidence-based data published up to date. Further studies are warranted.
Original languageEnglish
Article number110441
JournalMolecular and Cellular Endocrinology
Volume497
DOIs
Publication statusPublished - 1 Nov 2019

Keywords

  • Anorexia nervosa
  • Appetite regulation
  • Decision-making
  • Ghrelin
  • Neuropsychological performance

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