Abstract
Original language | English |
---|---|
Pages (from-to) | 2735-2748 |
Number of pages | 14 |
Journal | AIDS (London, England) |
Volume | 27 |
Issue number | 17 |
DOIs | |
Publication status | Published - Nov 2013 |
Access to Document
Other files and links
Fingerprint
Dive into the research topics of 'Associations between immune depression and cardiovascular events in HIV infection'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
Associations between immune depression and cardiovascular events in HIV infection. / Sabin, Caroline A.; Ryom, Lene; De Wit, Stephane et al.
In: AIDS (London, England), Vol. 27, No. 17, 11.2013, p. 2735-2748.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Associations between immune depression and cardiovascular events in HIV infection
AU - Sabin, Caroline A.
AU - Ryom, Lene
AU - De Wit, Stephane
AU - Mocroft, Amanda
AU - Phillips, Andrew N.
AU - Worm, Signe W.
AU - Weber, Rainer
AU - D’Arminio Monforte, Antonella
AU - Reiss, Peter
AU - Kamara, David
AU - El-Sadr, Wafaa
AU - Pradier, Christian
AU - Dabis, Francois
AU - Law, Matthew
AU - Lundgren, Jens
AU - Group, for the D:A:D Study
AU - Torres, Ferran
N1 - Cited By :46 Export Date: 17 February 2022 CODEN: AIDSE Correspondence Address: Sabin, C.A.; Research Department of Infection and Population Health, Rowland Hill Street, London NW3 2PF, United Kingdom; email: c.sabin@ucl.ac.uk Funding details: National Institute of Allergy and Infectious Diseases, NIAID, U01AI042170, U01AI046362, U01AI069907 References: Triant, V.A., Regan, S., Lee, H., Sax, P.E., Beigs, J.B., Grinspoon, S.K., Association of immunologic and virologic factors with myocardial infarction rates in a US healthcare system (2010) J Acquir Immune Defic Syndr, 55, pp. 615-619; Rasmussen, L.D., Engsig, F.N., Christensen, H., Gerstoft, J., Kronborg, G., Pedersen, C., Risk of cerebrovascular events in persons with and without HIV: A Danish nationwide population-based cohort study (2011) AIDS, 25, pp. 1637-1646; Lichtenstein, K.A., Armon, C., Buchacz, K., Chmiel, J.S., Buckner, K., Tedaldi, E.M., Low CD4R T cell count is a risk factor for cardiovascular disease events in the HIV Outpatient Study (2010) Clin Infect Dis, 51, pp. 435-447; Phillips, A.N., Neaton, J., Lundgren, J.D., The role of HIV in serious diseases other than AIDS (2008) AIDS, 22, pp. 2409-2418; Class of antiretroviral drugs and the risk of myocardial infarction (2007) N Engl J Med, 356, pp. 1723-1735. , The DAD Study Group; Chow, F., Regan, S., Feske, S., Meigs, J., Grinspoon, S., Triant, V., HIV is an independent risk factor for ischemic stroke in a US healthcare system (2012) Poster 820. 19th Conference on Retroviruses and Opportunistic Infections, Seattle, , 5-8 March; Phillips, A.N., Carr, A., Neuhaus, J., Visnegarwaa, F., Prineas, R., Burman, W.J., Interruption of antiretroviral therapy and risk of cardiovascular disease in persons with HIV-1 infection: Exploratory analyses from the SMART trial (2008) Antivir Ther, 13, pp. 177-187; Lang, S., Mary-Krause, M., Simon, A., Partisani, M., Gilquin, J., Cotte, L., HIV replication and immune status are independent predictors of the risk of myocardial infarction in HIV-infected individuals (2012) Clin Infect Dis, 55, pp. 600-607; Ford, E.S., Greenwald, J.H., Richterman, A.G., Rupert, A., Dutcher, L., Badralmaa, Y., Traditional risk factors and D-dimer predict incidence cardiovascular disease events in chronic HIV infection (2010) AIDS, 24, pp. 1509-1517; Klein, D., Hurley, L.B., Quesenberry Jr., C.P., Sidney, S., Do protease inhibitors increase the risk for coronary heart disease in patients with HIV-1 infection (2002) J Acquir Immune Defic Syndr, 30, pp. 471-477; Triant, V.A., Lee, H., Hadigan, C., Grinspoon, S.K., Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease (2007) J Clin Endocrinol Metab, 92, pp. 2506-2512; Chahine, L.M., Khoriaty, R.N., Tomford, W.J., Hussain, M.S., The changing face of neurosyphilis (2011) Int J Stroke, 6, pp. 136-143; De Giorgi, A., Fabbian, F., Pala, M., Bonetti, F., Babini, I., Bagnaresi, I., Cocaine and acute vascular diseases (2012) Curr Drug Abuse Rev, 5, pp. 129-134; Yeung, M., Bhalla, A., Birns, J., Recreational drug misuse and stroke (2011) Curr Drug Abuse Rev, 4, pp. 286-291; Tunstall-Pedoe, H., Kuulasmaa, K., Amouyel, P., Arveiler, D., Rajakangas, A.M., Pamak, A., Myocardial infarction and coronary deaths in the World Health Organization MONICA Project registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents (1994) Circulation, 90, pp. 583-612; Friis-Møller, N., Sabin, C.A., Weber, R., Darminio Monforte, A., El-Sadr, W.M., Reiss, P., The Data Collection on Adverse Events of Anti-HIV Drugs (DAD) Study Group. Combination antiretroviral therapy and the risk of myocardial infarction (2003) New Engl J Med, 349, pp. 1993-2003; Darminio Monforte, A., Sabin, C.A., Phillips, A.N., Reiss, P., Weber, R., Kirk, O., Cardio-and cerebrovascular events in HIV-infected persons (2004) AIDS, 18, pp. 1811-1817. , The Writing Committee of the D:A:D Study Group; Simanek, A.M., Dowd, J.B., Pawelec, G., Melzer, D., Dutta, A., Aiello, A.E., Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States (2011) PLoS One, 6, pp. e16103; Crane, H., Paramsothy, P., Heckbert, S., Budoff, M., Willig, J., Mugavero, M., Primary vs secondary MI events among HIVR individuals: The CNICS Cohort (2012) Poster 821. 19th Conference on Retroviruses and Opportunistic Infections, Seattle, , 5-8 March; Triant, V.A., HIV infection and coronary heart disease: An intersection of epidemics (2012) J Infect Dis, 205 (SUPPL. 3), pp. S355-S361; Neuhaus, J., Jacobs, D.R., Baker, J.V., Calmy, A., Duprez, D., La Rosa, A., Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection (2010) J Infect Dis, 201, pp. 1788-1795; Baker, J., Ayenew, W., Quick, H., Huppler Hullsiek, K., Tracy, R., Henry, K., High-density lipoprotein particles and markers of inflammation and thrombotic activity in patients with untreated HIV infection (2010) J Infect Dis, 201, pp. 285-292; Triant, V.A., Meigs, J.B., Grinspoon, S.K., Association of C-reactive protein and HIV infection with acute myocardial infarction (2009) J Acquir Immune Defic Syndr, 51, pp. 268-273; Protopopescu, C., Dupon, M., Hardel, L., Rabaud, C., Salmon, D., Couturier, F., CD4R cell count >200 cells/mm3 and moderate alcohol consumption in HIV-positive patients over 11 years of antiretroviral therapy: Evidence of protection against coronary and other arterial disease events Abstract THPE082, , XIX International AIDS Conference, Washington DC, US, 22-27 July 2012; Squillace, N., Zona, S., Stentarelli, C., Orlando, G., Beghetto, B., Nardini, G., Detectable HIV viral load is associated with metabolic syndrome (2009) J Acquir Immune Defic Syndr, 52, pp. 459-464; Hansen, B.R., Petersen, J., Haugaard, S.B., Madsbad, S., Obel, N., Suzuki, Y., The prevalence of metabolic syndrome in Danish patients with HIV infection: The effect of antiretroviral therapy (2009) HIV Med, 10, pp. 378-387; Alencastro, P.R., Fuchs, S.C., Wolff, F.H., Ikeda, M.L., Brandao, A.B.M., Barcellos, N.T., Independent predictors of metabolic syndrome in HIV-infected patients (2011) AIDS Patient Care STDS, 25, pp. 627-634; Butt, A.A., McGinnis, K., Rodriguez-Barradas, M.C., Crystal, S., Simberkoff, M., Bidwell Goetz, M., HIV infection and the risk of diabetes mellitus (2009) AIDS, 23, pp. 1227-1234; Lo, Y.C., Chen, M.Y., Sheng, W.H., Hsieh, S.M., Sun, H.Y., Liu, W.C., Risk factors for incident diabetes mellitus among HIV-infected patients receiving combination antiretroviral therapy in Taiwan: A case-control study (2009) HIV Med, 10, pp. 302-302; Guaraldi, G., Zona, S., Alexopoulos, N., Orlando, G., Carli, F., Ligabue, G., Coronary aging in HIV-infected patients (2009) Clin Infect Dis, 49, pp. 1756-1762; El-Sadr, W.M., Mullin, C.M., Carr, A., Gibert, C., Rappoport, C., Visnegarwala, F., Effects of HIV disease on lipid, glucose and insulin levels: Results from a large antiretroviral-nave cohort (2005) HIV Med, 6, pp. 114-121; Ho, J.E., Deeks, S.G., Hecht, F.M., Xie, Y., Schnell, A., Martin, J.N., Initiation of antiretroviral therapy at higher nadir CD4R T-cell counts is associated with reduced arterial stiffness in HIVinfected individuals (2010) AIDS, 24, pp. 1897-1905; De Saint Martin, L., Pasquier, E., Vandhuick, O., Arnaud, B., Vallet, S., Duchemin, J., Correlations between carotid IMT, factor VIII activity level and metabolic disturbances: A cardio-vascular risk factor in the HIV positive persons (2007) Curr HIV Res, 5, pp. 361-364; Ho, J.E., Scherzer, R., Hecht, F.M., Maka, K., Selby, V., Martin, J.N., The association of CD4R T-cell counts and cardiovascular risk in treated HIV disease (2012) AIDS, 26, pp. 1115-1120; Kaplan, R.C., Kingsley, L.A., Gange, S.J., Benning, L., Jacobson, L.P., Lazar, J., Low CD4R T-cell count as a major atherosclerosis risk factor in HIV-infected women and men (2008) AIDS, 22, pp. 1615-1624; Mangili, A., Polak, J.F., Skinner, S.C., Gerrior, J., Sheehan, H., Harrington, A., HIV infection and progression of carotid and coronary atherosclerosis: The CARE Study (2011) J Acquir Immune Defic Syndr, 58, pp. 148-153; Vinikook, M., Napravnik, S., Floris-Moore, M., Eron, J., Incidence and clinical features of cerebrovascular events in HIV-positive adults in the southeastern United States Abstract THPE092, , XIX International AIDS Conference, Washington DC, USA, 22-27 July 2012; Chapman, J.R., Clinical renal transplantation: Where are we now what are our key challenges (2010) Transplant Proc, 42 (9 SUPPL.), pp. S3-6
PY - 2013/11
Y1 - 2013/11
N2 - Objective: To consider associations between the latest/nadir CD4 + cell count, and time spent with CD4+ cell count less than 200 cells/ml (duration of immune depression), and myocardial infarction (MI), coronary heart disease (CHD), stroke, or cardiovascular disease (CVD) (CHD or stroke) in 33 301 HIV-positive individuals. Design: Longitudinal cohort study. Methods: Analyses were undertaken using Poisson regression. To investigate whether analyses of stroke were robust to the type of endpoint, we additionally included strokelike events and rejected strokes into the stroke endpoint. Results: Participants experienced 716 MI, 1056 CHD, 303 stroke, and 1284 CVD events. Whereas there was no evidence of a higher MI/CHD risk in those with lower latest/nadir CD4+ cell counts after adjustment [current CD4+<100 cells/ml: relative rate (95% confidence interval) 0.96 (0.62-1.50) for MI, 0.89 (0.30-2.36) for CHD; nadir CD4+<100 cells/ml: 1.36 (0.57-3.23) for MI, 0.98 (0.45-2.16) for CHD], stroke and CVD rates were higher in those with a latest CD4+ cell count less than 100 cells/ml [2.26 (1.29-3.94) and 1.14 (0.84-1.56), respectively]. All events occurred less frequently in those who had not experienced immune depression, although evidence for a linear association with duration of immune depression was weak. The association between stroke risk and the latest CD4+ cell count strengthened as stroke-like and rejected strokes were included; conversely, associations with established stroke risk factors weakened. Conclusion: We do not find strong evidence that HIV-positive individuals with a low CD4+ cell count are more likely to experience MI/CHD.Although strokes appear to occur more commonly at low CD4+ cell counts, this may be partly explained by misclassification or other biases. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
AB - Objective: To consider associations between the latest/nadir CD4 + cell count, and time spent with CD4+ cell count less than 200 cells/ml (duration of immune depression), and myocardial infarction (MI), coronary heart disease (CHD), stroke, or cardiovascular disease (CVD) (CHD or stroke) in 33 301 HIV-positive individuals. Design: Longitudinal cohort study. Methods: Analyses were undertaken using Poisson regression. To investigate whether analyses of stroke were robust to the type of endpoint, we additionally included strokelike events and rejected strokes into the stroke endpoint. Results: Participants experienced 716 MI, 1056 CHD, 303 stroke, and 1284 CVD events. Whereas there was no evidence of a higher MI/CHD risk in those with lower latest/nadir CD4+ cell counts after adjustment [current CD4+<100 cells/ml: relative rate (95% confidence interval) 0.96 (0.62-1.50) for MI, 0.89 (0.30-2.36) for CHD; nadir CD4+<100 cells/ml: 1.36 (0.57-3.23) for MI, 0.98 (0.45-2.16) for CHD], stroke and CVD rates were higher in those with a latest CD4+ cell count less than 100 cells/ml [2.26 (1.29-3.94) and 1.14 (0.84-1.56), respectively]. All events occurred less frequently in those who had not experienced immune depression, although evidence for a linear association with duration of immune depression was weak. The association between stroke risk and the latest CD4+ cell count strengthened as stroke-like and rejected strokes were included; conversely, associations with established stroke risk factors weakened. Conclusion: We do not find strong evidence that HIV-positive individuals with a low CD4+ cell count are more likely to experience MI/CHD.Although strokes appear to occur more commonly at low CD4+ cell counts, this may be partly explained by misclassification or other biases. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
KW - bias
KW - cardiovascular disease
KW - CD4<sup xmlns:mrws="http://webservices.ovid.com/mrws/1.0">+</sup> lymphocyte count
KW - myocardial infarction
KW - stroke
UR - http://www.ncbi.nlm.nih.gov/pubmed/23842128
U2 - 10.1097/01.aids.0000432457.91228.f3
DO - 10.1097/01.aids.0000432457.91228.f3
M3 - Article
C2 - 23842128
VL - 27
SP - 2735
EP - 2748
IS - 17
ER -