Association of low serum 25-hydroxyvitamin D levels and high arterial blood pressure in the elderly

J Almirall, M Vaqueiro, M Baré

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52 Citations (Scopus)


Background. Vitamin D and calcium metabolism are involved in vascular smooth muscle cell proliferation, endothelial function and blood pressure (BP) regulation. Their physiopathology has been a matter of intensive clinical investigation with variable and sometimes contradictory results. Vitamin D insufficiency is highly prevalent in the general population, particularly among the elderly. We evaluated the association between serum 25(OH)-D levels and arterial BP in this population.Methods. An epidemiological cross-sectional study was designed to analyse the prevalence of hypovitaminosis D ('D'AVIS' study) in our reference area. The study was performed on a representative random sample of the population over 64 years of age obtained from five primary health care areas. A medical record, arterial BP and biological analysis: serum 25(OH)-D, iPTH, creatinine, urea, calcium, albumin were obtained.Results. A total of 237 subjects (53 women), aged between 64 and 93 (mean 71.7 ± 5.3), were evaluated. The mean serum 25(OH)-D levels were 17.21 ± 7.57 ngml (interval 5-54; 86 had <25 ngml). The mean BP was 138.8 ± 1480 ± 7.4 mmHg, and 46 were on antihypertensive treatment. A significant negative association was observed between serum 25(OH)-D levels and systolic (r =-0.153, P = 0.018) and diastolic BP (r =-0.152, P = 0.019). This association persisted after controlling for possible confounders in the multivariate analyses.Conclusions. Low serum 25(OH)-D levels were inversely and independently associated with BP. Supplemental measures to prevent hypovitaminosis D in this population would be important, not only to protect the skeletal system but also for the possible beneficial effects on the cardiovascular system and the BP regulation.
Original languageEnglish
Pages (from-to)503-509
JournalNephrology Dialysis Transplantation
Issue number2
Publication statusPublished - 1 Feb 2010


  • Blood pressure
  • Cross-sectional study
  • Elderly
  • Hypertension
  • Vitamin D


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