We aimed to assess the relationship between the presence of antibodies against cytoplasmic islet cell antigens (ICA) and glutamic acid decarboxylase (GAD) and residual β-cell function during the first year after the clinical onset of IDDM in adult subjects. Thirty-two adult subjects at onset of IDDM were prospectively followed up during the first year after the diagnosis. ICA, GAD antibodies and residual β-cell function (serum C-peptide after i.v. glucagon) were assessed at 0, 3, 6 and 12 months of disease duration. Subjects positive for ICA at onset and persistently positive throughout the first year of the disease had higher stimulated C-peptide levels at 6 months as compared to ICA negative subjects (p < 0.03) and those with non-persistent antibody positivity (p < 0.03). The presence of GAD antibodies during this period did not show any correlation with β-cell function. However, the presence of GAD antibodies was associated to higher insulin requirements during the study period. The presence of ICA during the first year after diagnosis in subjects with adult-onset IDDM is associated with a slower progression of residual β-cell destruction. GAD antibody positivity during the same time period is associated to higher insulin requirements.
|Journal||Diabetes, Nutrition and Metabolism - Clinical and Experimental|
|Publication status||Published - 1 Aug 1997|