Association of hepatitis E virus (HEV) and postweaning multisystemic wasting syndrome (PMWS) with lesions of hepatitis in pigs

M. Martín, J. Segalés, F. F. Huang, D. K. Guenette, E. Mateu, N. de Deus, X. J. Meng

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Abstract

The aim of the study was to determine the presence of swine hepatitis E virus (HEV) RNA and antibodies in postweaning multisystemic wasting syndrome-affected (n = 114) and non-affected (n = 46) pigs and the possible association with hepatitis lesions. Forty-four pigs were RT-PCR positive (28.2%); 25 of them were PMWS cases, while 19 were non-PMWS pigs. In both groups, HEV RT-PCR results were associated with hepatitis (OR = 5.61 for PMWS-affected pigs and OR = 5.17 for non-PMWS affected pigs; p = 0.01). No interaction was detected in a logistic regression between PMWS occurrence and HEV infection for the development of hepatitis lesions. Seropositivity to HEV was more likely to occur in pigs with hepatitis (51.9%) compared to pigs without hepatitis (36.1%; p = 0.03). Significant differences in optical densities were notices comparing the lesional stage of pigs (p = 0.009). While pigs with slight or moderate hepatitis were seropositive, pigs with more severe lesions were seronegative to HEV. These results indicate that swine HEV infection can be a significant contributor to the development of moderate hepatitis in pigs regardless of the PMWS status. © 2007 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)16-24
JournalVeterinary Microbiology
Volume122
DOIs
Publication statusPublished - 16 May 2007

Keywords

  • HEV
  • Hepatitis E
  • Porcine circovirus type 2
  • Postweaning multisystemic wasting syndrome
  • Swine

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