Association of bla<inf>DHA-1</inf> and qnrB genes carried by broad-host-range plasmids among isolates of Enterobacteriaceae at a Spanish hospital

C. Mata, E. Miró, M. Toleman, M. A. Rivera, T. R. Walsh, F. Navarro

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13 Citations (Scopus)

Abstract

A collection of 30 DHA-1-Enterobacteriaceae producers was examined for the presence of qnr genes. PCR-based replicon typing, plasmid profile and Southern hybridisation analyses revealed that all isolates co-harboured blaDHA-1 and qnrB genes on the same plasmid. All but one of these plasmids belonged to the L/M group. Genetic organization analyses of a randomly selected isolate revealed the co-localization of both genes on an IS26-composite transposon. As plasmids carrying both genes seem to have a high prevalence and a worldwide distribution, care should be taken when quinolones are used to treat infections caused by DHA-1 producers. © 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.
Original languageEnglish
Pages (from-to)1514-1517
JournalClinical Microbiology and Infection
Volume17
Issue number10
DOIs
Publication statusPublished - 1 Jan 2011

Keywords

  • IncN
  • IS26-composite transposon
  • L/M incompatibility group
  • Plasmid-mediated AmpC β-lactamases
  • Plasmid-mediated quinolone resistance

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