Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population

N Babio; L Compañ-Gabucio; R Granero; J Konieczna; X Pintó; J Lapetra; P Matía-Martín; C Lassale; N Cano-Ibáñez; J Vidal; I Baenas; Á M Alonso-Gómez; J V Sorli; M A Zulet; J L Serra-Majem; L Camacho-Barcia; M Á Muñoz-Pérez; M García-de-la-Hera; J A Martínez; F J Tinahones; A Garcia-Arellano; L Tojal-Sierra; J J Gaforio; J Wärnberg; F J Basterra-Gortari; J Salas-Salvadó; C Vázquez; O Portoles; A P Arenas-Larriva; M Fitó; S Eguaras; S de Las Heras-Delgado; D Romaguera; R M Baños; S Martín-Peláez; D Corella; O Castañer-Niño; S Dalsgaard; F Fernández-Aranda; R Estruch; C Razquin; J A Tur; S Jiménez-Murcia; V Martín-Sánchez; S Shyam; J López-Miranda; L Daimiel; E Gómez-García; J Vioque; E Ros; C Gómez-Martínez

doi:10.1007/s40618-023-02278-y

Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population

N Babio, L Compañ-Gabucio, R Granero, J Konieczna, X Pintó, J Lapetra, P Matía-Martín, C Lassale, N Cano-Ibáñez, J Vidal, I Baenas, Á M Alonso-Gómez, J V Sorli, M A Zulet, J L Serra-Majem, L Camacho-Barcia, M Á Muñoz-Pérez, M García-de-la-Hera, J A Martínez, F J TinahonesA Garcia-Arellano, L Tojal-Sierra, J J Gaforio, J Wärnberg, F J Basterra-Gortari, J Salas-Salvadó, C Vázquez, O Portoles, A P Arenas-Larriva, M Fitó, S Eguaras, S de Las Heras-Delgado, D Romaguera, R M Baños, S Martín-Peláez, D Corella, O Castañer-Niño, S Dalsgaard, F Fernández-Aranda, R Estruch, C Razquin, J A Tur, S Jiménez-Murcia, V Martín-Sánchez, S Shyam, J López-Miranda, L Daimiel, E Gómez-García, J Vioque, E Ros, C Gómez-Martínez

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Abstract

Objectives To examine the cross-sectional association between baseline depressive symptoms and the presence of type 2 diabetes (T2D), and its association with glycated hemoglobin (HbA1c) and other metabolic variables, and the prospective association of depressive symptoms and HbA1c after 1 year of follow-up.Methods n = 6224 Mediterranean older adults with overweight/obesity and metabolic syndrome (48% females, mean age 64.9 +/- 4.9 years) were evaluated in the framework of the PREDIMED-Plus study cohort. Depressive symptoms were assessed using the Beck Depression Inventory-II and HbA1c was used to measure metabolic control.Results The presence of T2D increased the likelihood of higher levels of depressive symptoms (chi(2)= 15.84, p = 0.001). Polynomial contrast revealed a positive linear relationship (chi(2)= 13.49, p = 0.001), the higher the depressive symptoms levels, the higher the prevalence of T2D. Longitudinal analyses showed that the higher baseline depressive symptoms levels, the higher the likelihood of being within the HbA1c >= 7% at 1-year level (Wald-chi(2) = 24.06, df = 3, p < .001, for the full adjusted model). Additionally, depressive levels at baseline and duration of T2D predicted higher HbA1c and body mass index, and lower physical activity and adherence to Mediterranean Diet at 1 year of follow-up.Conclusions This study supports an association between T2D and the severity of depressive symptoms, suggesting a worse metabolic control from mild severity levels in the short-medium term, influenced by lifestyle habits related to diabetes care. Screening for depressive symptoms and a multidisciplinary integrative therapeutic approach should be ensured in patients with T2D.

Original language	English
Pages (from-to)	1405-1418
Number of pages	14
Journal	Journal of endocrinological investigation
Volume	47
Issue number	6
DOIs	https://doi.org/10.1007/s40618-023-02278-y
Publication status	Published - 13 Jan 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Type 2 diabetes
Body Mass Index
Glycated Hemoglobin/analysis
Metabolic Syndrome/epidemiology
Prevalence
Prospective Studies
Cross-Sectional Studies
Diet, Mediterranean
Follow-Up Studies
Humans
Middle Aged
Male
Severity
Metabolic syndrome
Depression/epidemiology
Diabetes Mellitus, Type 2/psychology
Depressive symptoms
Female
Aged
Obesity/psychology
HbA1c

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10.1007/s40618-023-02278-yLicence: CC BY

https://ddd.uab.cat/record/293835

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Babio, N., Compañ-Gabucio, L., Granero, R., Konieczna, J., Pintó, X., Lapetra, J., Matía-Martín, P., Lassale, C., Cano-Ibáñez, N., Vidal, J., Baenas, I., Alonso-Gómez, Á. M., Sorli, J. V., Zulet, M. A., Serra-Majem, J. L., Camacho-Barcia, L., Muñoz-Pérez, M. Á., García-de-la-Hera, M., Martínez, J. A., ... Gómez-Martínez, C. (2024). Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population. Journal of endocrinological investigation, 47(6), 1405-1418. https://doi.org/10.1007/s40618-023-02278-y

@article{87d516d950564ce4bfa4edcd93c23310,

title = "Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population",

abstract = "Objectives To examine the cross-sectional association between baseline depressive symptoms and the presence of type 2 diabetes (T2D), and its association with glycated hemoglobin (HbA1c) and other metabolic variables, and the prospective association of depressive symptoms and HbA1c after 1 year of follow-up.Methods n = 6224 Mediterranean older adults with overweight/obesity and metabolic syndrome (48\% females, mean age 64.9 +/- 4.9 years) were evaluated in the framework of the PREDIMED-Plus study cohort. Depressive symptoms were assessed using the Beck Depression Inventory-II and HbA1c was used to measure metabolic control.Results The presence of T2D increased the likelihood of higher levels of depressive symptoms (chi(2)= 15.84, p = 0.001). Polynomial contrast revealed a positive linear relationship (chi(2)= 13.49, p = 0.001), the higher the depressive symptoms levels, the higher the prevalence of T2D. Longitudinal analyses showed that the higher baseline depressive symptoms levels, the higher the likelihood of being within the HbA1c >= 7\% at 1-year level (Wald-chi(2) = 24.06, df = 3, p < .001, for the full adjusted model). Additionally, depressive levels at baseline and duration of T2D predicted higher HbA1c and body mass index, and lower physical activity and adherence to Mediterranean Diet at 1 year of follow-up.Conclusions This study supports an association between T2D and the severity of depressive symptoms, suggesting a worse metabolic control from mild severity levels in the short-medium term, influenced by lifestyle habits related to diabetes care. Screening for depressive symptoms and a multidisciplinary integrative therapeutic approach should be ensured in patients with T2D.",

keywords = "Type 2 diabetes, Body Mass Index, Glycated Hemoglobin/analysis, Metabolic Syndrome/epidemiology, Prevalence, Prospective Studies, Cross-Sectional Studies, Diet, Mediterranean, Follow-Up Studies, Humans, Middle Aged, Male, Severity, Metabolic syndrome, Depression/epidemiology, Diabetes Mellitus, Type 2/psychology, Depressive symptoms, Female, Aged, Obesity/psychology, HbA1c",

author = "N Babio and L Compa{\~n}-Gabucio and R Granero and J Konieczna and X Pint{\'o} and J Lapetra and P Mat{\'i}a-Mart{\'i}n and C Lassale and N Cano-Ib{\'a}{\~n}ez and J Vidal and I Baenas and Alonso-G{\'o}mez, \{{\'A} M\} and Sorli, \{J V\} and Zulet, \{M A\} and Serra-Majem, \{J L\} and L Camacho-Barcia and Mu{\~n}oz-P{\'e}rez, \{M {\'A}\} and M Garc{\'i}a-de-la-Hera and Mart{\'i}nez, \{J A\} and Tinahones, \{F J\} and A Garcia-Arellano and L Tojal-Sierra and Gaforio, \{J J\} and J W{\"a}rnberg and Basterra-Gortari, \{F J\} and J Salas-Salvad{\'o} and C V{\'a}zquez and O Portoles and Arenas-Larriva, \{A P\} and M Fit{\'o} and S Eguaras and \{de Las Heras-Delgado\}, S and D Romaguera and Ba{\~n}os, \{R M\} and S Mart{\'i}n-Pel{\'a}ez and D Corella and O Casta{\~n}er-Ni{\~n}o and S Dalsgaard and F Fern{\'a}ndez-Aranda and R Estruch and C Razquin and Tur, \{J A\} and S Jim{\'e}nez-Murcia and V Mart{\'i}n-S{\'a}nchez and S Shyam and J L{\'o}pez-Miranda and L Daimiel and E G{\'o}mez-Garc{\'i}a and J Vioque and E Ros and C G{\'o}mez-Mart{\'i}nez",

note = "Publisher Copyright: {\textcopyright} 2024, The Author(s).",

year = "2024",

month = jan,

day = "13",

doi = "10.1007/s40618-023-02278-y",

language = "English",

volume = "47",

pages = "1405--1418",

journal = "Journal of endocrinological investigation",

issn = "0391-4097",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "6",

}

Babio, N, Compañ-Gabucio, L, Granero, R, Konieczna, J, Pintó, X, Lapetra, J, Matía-Martín, P, Lassale, C, Cano-Ibáñez, N, Vidal, J, Baenas, I, Alonso-Gómez, ÁM, Sorli, JV, Zulet, MA, Serra-Majem, JL, Camacho-Barcia, L, Muñoz-Pérez, MÁ, García-de-la-Hera, M, Martínez, JA, Tinahones, FJ, Garcia-Arellano, A, Tojal-Sierra, L, Gaforio, JJ, Wärnberg, J, Basterra-Gortari, FJ, Salas-Salvadó, J, Vázquez, C, Portoles, O, Arenas-Larriva, AP, Fitó, M, Eguaras, S, de Las Heras-Delgado, S, Romaguera, D, Baños, RM, Martín-Peláez, S, Corella, D, Castañer-Niño, O, Dalsgaard, S, Fernández-Aranda, F, Estruch, R, Razquin, C, Tur, JA, Jiménez-Murcia, S, Martín-Sánchez, V, Shyam, S, López-Miranda, J, Daimiel, L, Gómez-García, E, Vioque, J, Ros, E & Gómez-Martínez, C 2024, 'Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population', Journal of endocrinological investigation, vol. 47, no. 6, pp. 1405-1418. https://doi.org/10.1007/s40618-023-02278-y

TY - JOUR

T1 - Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population

AU - Babio, N

AU - Compañ-Gabucio, L

AU - Granero, R

AU - Konieczna, J

AU - Pintó, X

AU - Lapetra, J

AU - Matía-Martín, P

AU - Lassale, C

AU - Cano-Ibáñez, N

AU - Vidal, J

AU - Baenas, I

AU - Alonso-Gómez, Á M

AU - Sorli, J V

AU - Zulet, M A

AU - Serra-Majem, J L

AU - Camacho-Barcia, L

AU - Muñoz-Pérez, M Á

AU - García-de-la-Hera, M

AU - Martínez, J A

AU - Tinahones, F J

AU - Garcia-Arellano, A

AU - Tojal-Sierra, L

AU - Gaforio, J J

AU - Wärnberg, J

AU - Basterra-Gortari, F J

AU - Salas-Salvadó, J

AU - Vázquez, C

AU - Portoles, O

AU - Arenas-Larriva, A P

AU - Fitó, M

AU - Eguaras, S

AU - de Las Heras-Delgado, S

AU - Romaguera, D

AU - Baños, R M

AU - Martín-Peláez, S

AU - Corella, D

AU - Castañer-Niño, O

AU - Dalsgaard, S

AU - Fernández-Aranda, F

AU - Estruch, R

AU - Razquin, C

AU - Tur, J A

AU - Jiménez-Murcia, S

AU - Martín-Sánchez, V

AU - Shyam, S

AU - López-Miranda, J

AU - Daimiel, L

AU - Gómez-García, E

AU - Vioque, J

AU - Ros, E

AU - Gómez-Martínez, C

PY - 2024/1/13

Y1 - 2024/1/13

N2 - Objectives To examine the cross-sectional association between baseline depressive symptoms and the presence of type 2 diabetes (T2D), and its association with glycated hemoglobin (HbA1c) and other metabolic variables, and the prospective association of depressive symptoms and HbA1c after 1 year of follow-up.Methods n = 6224 Mediterranean older adults with overweight/obesity and metabolic syndrome (48% females, mean age 64.9 +/- 4.9 years) were evaluated in the framework of the PREDIMED-Plus study cohort. Depressive symptoms were assessed using the Beck Depression Inventory-II and HbA1c was used to measure metabolic control.Results The presence of T2D increased the likelihood of higher levels of depressive symptoms (chi(2)= 15.84, p = 0.001). Polynomial contrast revealed a positive linear relationship (chi(2)= 13.49, p = 0.001), the higher the depressive symptoms levels, the higher the prevalence of T2D. Longitudinal analyses showed that the higher baseline depressive symptoms levels, the higher the likelihood of being within the HbA1c >= 7% at 1-year level (Wald-chi(2) = 24.06, df = 3, p < .001, for the full adjusted model). Additionally, depressive levels at baseline and duration of T2D predicted higher HbA1c and body mass index, and lower physical activity and adherence to Mediterranean Diet at 1 year of follow-up.Conclusions This study supports an association between T2D and the severity of depressive symptoms, suggesting a worse metabolic control from mild severity levels in the short-medium term, influenced by lifestyle habits related to diabetes care. Screening for depressive symptoms and a multidisciplinary integrative therapeutic approach should be ensured in patients with T2D.

AB - Objectives To examine the cross-sectional association between baseline depressive symptoms and the presence of type 2 diabetes (T2D), and its association with glycated hemoglobin (HbA1c) and other metabolic variables, and the prospective association of depressive symptoms and HbA1c after 1 year of follow-up.Methods n = 6224 Mediterranean older adults with overweight/obesity and metabolic syndrome (48% females, mean age 64.9 +/- 4.9 years) were evaluated in the framework of the PREDIMED-Plus study cohort. Depressive symptoms were assessed using the Beck Depression Inventory-II and HbA1c was used to measure metabolic control.Results The presence of T2D increased the likelihood of higher levels of depressive symptoms (chi(2)= 15.84, p = 0.001). Polynomial contrast revealed a positive linear relationship (chi(2)= 13.49, p = 0.001), the higher the depressive symptoms levels, the higher the prevalence of T2D. Longitudinal analyses showed that the higher baseline depressive symptoms levels, the higher the likelihood of being within the HbA1c >= 7% at 1-year level (Wald-chi(2) = 24.06, df = 3, p < .001, for the full adjusted model). Additionally, depressive levels at baseline and duration of T2D predicted higher HbA1c and body mass index, and lower physical activity and adherence to Mediterranean Diet at 1 year of follow-up.Conclusions This study supports an association between T2D and the severity of depressive symptoms, suggesting a worse metabolic control from mild severity levels in the short-medium term, influenced by lifestyle habits related to diabetes care. Screening for depressive symptoms and a multidisciplinary integrative therapeutic approach should be ensured in patients with T2D.

KW - Type 2 diabetes

KW - Body Mass Index

KW - Glycated Hemoglobin/analysis

KW - Metabolic Syndrome/epidemiology

KW - Prevalence

KW - Prospective Studies

KW - Cross-Sectional Studies

KW - Diet, Mediterranean

KW - Follow-Up Studies

KW - Humans

KW - Middle Aged

KW - Male

KW - Severity

KW - Metabolic syndrome

KW - Depression/epidemiology

KW - Diabetes Mellitus, Type 2/psychology

KW - Depressive symptoms

KW - Female

KW - Aged

KW - Obesity/psychology

KW - HbA1c

UR - http://www.ncbi.nlm.nih.gov/pubmed/38218741

UR - https://www.scopus.com/pages/publications/85182212511

UR - https://ddd.uab.cat/record/293835

UR - https://www.mendeley.com/catalogue/522f7344-16a1-3bd0-9db6-9e2cc6532515/

U2 - 10.1007/s40618-023-02278-y

DO - 10.1007/s40618-023-02278-y

M3 - Article

C2 - 38218741

SN - 0391-4097

VL - 47

SP - 1405

EP - 1418

JO - Journal of endocrinological investigation

JF - Journal of endocrinological investigation

IS - 6

ER -

Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population

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Keywords

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