TY - JOUR
T1 - Association between nailfold capillaroscopy findings and pulmonary function tests in patients with with systemic sclerosis
AU - Castellví, Ivan
AU - Simeón-Aznar, Carmen Pilar
AU - Sarmiento, Mónica
AU - Fortuna, Ana
AU - Mayos, Mercedes
AU - Geli, Carme
AU - Diaz-Torné, César
AU - Moya, Patricia
AU - De Llobet, Josep Maria
AU - Casademont, Jordi
PY - 2015/1/1
Y1 - 2015/1/1
N2 - © 2015. All rights reserved. Objective. To determine whether there is an association between different capillaroscopic findings and pulmonary function tests in systemic sclerosis (SSc). Methods. We did a retrospective observational study in a cohort of patients with SSc and early SSc. Patients with at least 1 nailfold videocapillaroscopy (NVC) magnified 120× were included. Pathological findings were giant capillaries, angiogenesis, and density loss. Findings were compared with lung function values: percent expected value of forced vital capacity (FVC), DLCO, and FVC/DLCO ratio. Other variables collected were sex and SSc type, and the presence of digital ulcers (DU), interstitial lung disease (ILD), scleroderma renal crisis, and/or pulmonary hypertension (PH). Results. Of 136 patients with SSc, 85 had undergone an NVC. The frequency of ILD, DU, and PH was 24.1%, 28.7%, and 17.2%, respectively. Data analysis showed that patients with density loss had worse FVC% (86.91 ± 19.42 vs 101.13 ± 16.06, p < 0.01) and DLCO% (71.43 ± 21.19 vs 85.9 ± 19.81, p < 0.01) compared to those without. Conclusion. Patients with loss of density present worse FVC and DLCO values. Prospective studies are warranted to determine whether NVC is useful for studying pulmonary function in SSc.
AB - © 2015. All rights reserved. Objective. To determine whether there is an association between different capillaroscopic findings and pulmonary function tests in systemic sclerosis (SSc). Methods. We did a retrospective observational study in a cohort of patients with SSc and early SSc. Patients with at least 1 nailfold videocapillaroscopy (NVC) magnified 120× were included. Pathological findings were giant capillaries, angiogenesis, and density loss. Findings were compared with lung function values: percent expected value of forced vital capacity (FVC), DLCO, and FVC/DLCO ratio. Other variables collected were sex and SSc type, and the presence of digital ulcers (DU), interstitial lung disease (ILD), scleroderma renal crisis, and/or pulmonary hypertension (PH). Results. Of 136 patients with SSc, 85 had undergone an NVC. The frequency of ILD, DU, and PH was 24.1%, 28.7%, and 17.2%, respectively. Data analysis showed that patients with density loss had worse FVC% (86.91 ± 19.42 vs 101.13 ± 16.06, p < 0.01) and DLCO% (71.43 ± 21.19 vs 85.9 ± 19.81, p < 0.01) compared to those without. Conclusion. Patients with loss of density present worse FVC and DLCO values. Prospective studies are warranted to determine whether NVC is useful for studying pulmonary function in SSc.
KW - Capillaroscopy
KW - Nailfold videocapillaroscopy
KW - Pulmonary function tests
KW - Systemic sclerosis
U2 - 10.3899/jrheum.140276
DO - 10.3899/jrheum.140276
M3 - Article
VL - 42
SP - 222
EP - 227
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 2
ER -