Association between nailfold capillaroscopy findings and pulmonary function tests in patients with with systemic sclerosis

Ivan Castellví, Carmen Pilar Simeón-Aznar, Mónica Sarmiento, Ana Fortuna, Mercedes Mayos, Carme Geli, César Diaz-Torné, Patricia Moya, Josep Maria De Llobet, Jordi Casademont

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

© 2015. All rights reserved. Objective. To determine whether there is an association between different capillaroscopic findings and pulmonary function tests in systemic sclerosis (SSc). Methods. We did a retrospective observational study in a cohort of patients with SSc and early SSc. Patients with at least 1 nailfold videocapillaroscopy (NVC) magnified 120× were included. Pathological findings were giant capillaries, angiogenesis, and density loss. Findings were compared with lung function values: percent expected value of forced vital capacity (FVC), DLCO, and FVC/DLCO ratio. Other variables collected were sex and SSc type, and the presence of digital ulcers (DU), interstitial lung disease (ILD), scleroderma renal crisis, and/or pulmonary hypertension (PH). Results. Of 136 patients with SSc, 85 had undergone an NVC. The frequency of ILD, DU, and PH was 24.1%, 28.7%, and 17.2%, respectively. Data analysis showed that patients with density loss had worse FVC% (86.91 ± 19.42 vs 101.13 ± 16.06, p < 0.01) and DLCO% (71.43 ± 21.19 vs 85.9 ± 19.81, p < 0.01) compared to those without. Conclusion. Patients with loss of density present worse FVC and DLCO values. Prospective studies are warranted to determine whether NVC is useful for studying pulmonary function in SSc.
Original languageEnglish
Pages (from-to)222-227
JournalJournal of Rheumatology
Volume42
Issue number2
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Capillaroscopy
  • Nailfold videocapillaroscopy
  • Pulmonary function tests
  • Systemic sclerosis

Fingerprint Dive into the research topics of 'Association between nailfold capillaroscopy findings and pulmonary function tests in patients with with systemic sclerosis'. Together they form a unique fingerprint.

Cite this