Assessment of rectocolonic morphology and function in patients with chagas disease in Barcelona (Spain)

Fernando Salvador, Marianela Mego, Adrián Sánchez-Montalvá, María Morís, Kathleen Ramírez, Ana Accarino, Juan Ramon Malagelada, Fernando Azpiroz, Israel Molina

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Copyright © 2015 by The American Society of Tropical Medicine and Hygiene. The aim of this study was to determine the relationship between colonic symptoms, radiological abnormalities, and anorectal dysfunction in patients with Chagas disease. We performed a cross-sectional study of untreated patients diagnosed with Chagas disease. All patients were evaluated clinically (by a questionnaire for colonic symptoms based on Rome III criteria) and underwent a barium enema and anorectal manometry. A control group of patients with functional constipation and without Chagas disease was included in the study. Overall, 69 patients were included in the study: 42 patients were asymptomatic and 27 patients had abdominal symptoms according to Rome III criteria. Anorectal manometry showed a higher proportion of abnormalities in symptomatic patients than in asymptomatic ones (73% versus 21%, respectively; P < 0.0001). Megarectum was detected in a similar proportion in the different subgroups regardless of the presence of symptoms or abnormalities in anorectal functions. Among non-Chagas disease patients with functional constipation, 90% had an abnormal anorectal manometry study. Patients with Chagas disease present a high proportion of constipation with dyssynergic defecation in anorectal manometry but a low prevalence of impaired rectoanal inhibitory reflex, although these abnormalities may be nonspecific for Chagas disease. The presence of megarectum is a nonspecific finding.
Original languageEnglish
Pages (from-to)898-902
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume92
Issue number5
DOIs
Publication statusPublished - 1 Jan 2015

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