Assessment of metallic alloys biocompatibility

Carme Nogués; Andreu Blanquer; Lleonard Barrios; Elena Ibañez

doi:10.1007/978-3-319-68025-5_16

Assessment of metallic alloys biocompatibility

Carme Nogués, Andreu Blanquer, Lleonard Barrios, Elena Ibañez

Research output: Chapter in Book › Chapter › Research › peer-review

Abstract

© Springer International Publishing AG 2018. All rights reserved. Metallic alloys have been widely used for orthopedic implants since the beginning of the last century. Compared to ceramics and polymers, metallic alloys present excellent mechanical properties and biocompatibility. In this chapter, we review the different in vitro assays currently used to test the biocompatibility of new materials designed to be used in orthopedics: cell adhesion, proliferation and differentiation, mineralization of the extracellular matrix and detection of inflammatory response. In addition, the known causes of alloy toxicity, namely ion release due to material corrosion and characteristics of the material surface (wettability, charge, or topography), are also discussed.

Original language	English
Title of host publication	Biomaterials in Clinical Practice: Advances in Clinical Research and Medical Devices
Editors	F Zivic, S Affatato, M Trajanovic, M Schnabelrauch, N Grujovic, K Choy
Pages	461-475
DOIs	https://doi.org/10.1007/978-3-319-68025-5_16
Publication status	Published - 2018

Keywords

Biocompatibility
In vitro assays
Metallic alloys
Ti-based alloys

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10.1007/978-3-319-68025-5_16

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title = "Assessment of metallic alloys biocompatibility",

abstract = "{\textcopyright} Springer International Publishing AG 2018. All rights reserved. Metallic alloys have been widely used for orthopedic implants since the beginning of the last century. Compared to ceramics and polymers, metallic alloys present excellent mechanical properties and biocompatibility. In this chapter, we review the different in vitro assays currently used to test the biocompatibility of new materials designed to be used in orthopedics: cell adhesion, proliferation and differentiation, mineralization of the extracellular matrix and detection of inflammatory response. In addition, the known causes of alloy toxicity, namely ion release due to material corrosion and characteristics of the material surface (wettability, charge, or topography), are also discussed.",

keywords = "Biocompatibility, In vitro assays, Metallic alloys, Ti-based alloys",

author = "Carme Nogu{\'e}s and Andreu Blanquer and Lleonard Barrios and Elena Iba{\~n}ez",

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doi = "10.1007/978-3-319-68025-5_16",

language = "English",

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TY - CHAP

T1 - Assessment of metallic alloys biocompatibility

AU - Nogués, Carme

AU - Blanquer, Andreu

AU - Barrios, Lleonard

AU - Ibañez, Elena

PY - 2018

Y1 - 2018

N2 - © Springer International Publishing AG 2018. All rights reserved. Metallic alloys have been widely used for orthopedic implants since the beginning of the last century. Compared to ceramics and polymers, metallic alloys present excellent mechanical properties and biocompatibility. In this chapter, we review the different in vitro assays currently used to test the biocompatibility of new materials designed to be used in orthopedics: cell adhesion, proliferation and differentiation, mineralization of the extracellular matrix and detection of inflammatory response. In addition, the known causes of alloy toxicity, namely ion release due to material corrosion and characteristics of the material surface (wettability, charge, or topography), are also discussed.

AB - © Springer International Publishing AG 2018. All rights reserved. Metallic alloys have been widely used for orthopedic implants since the beginning of the last century. Compared to ceramics and polymers, metallic alloys present excellent mechanical properties and biocompatibility. In this chapter, we review the different in vitro assays currently used to test the biocompatibility of new materials designed to be used in orthopedics: cell adhesion, proliferation and differentiation, mineralization of the extracellular matrix and detection of inflammatory response. In addition, the known causes of alloy toxicity, namely ion release due to material corrosion and characteristics of the material surface (wettability, charge, or topography), are also discussed.

KW - Biocompatibility

KW - In vitro assays

KW - Metallic alloys

KW - Ti-based alloys

U2 - 10.1007/978-3-319-68025-5_16

DO - 10.1007/978-3-319-68025-5_16

M3 - Chapter

SN - 978-3-319-68024-8

SP - 461

EP - 475

BT - Biomaterials in Clinical Practice: Advances in Clinical Research and Medical Devices

A2 - Zivic, F

A2 - Affatato, S

A2 - Trajanovic, M

A2 - Schnabelrauch, M

A2 - Grujovic, N

A2 - Choy, K

ER -

Assessment of metallic alloys biocompatibility

Abstract

Keywords

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