Assessment and management of opioid withdrawal symptoms in buprenorphine‐dependent subjects

Luis SAN; JORDI CAMÍ; TERESA FERNÁNDEZ; JOSÉ M. OLLÉ; JOSÉ M. PERI; MARTA TORRENS

doi:10.1111/j.1360-0443.1992.tb01900.x

Assessment and management of opioid withdrawal symptoms in buprenorphine‐dependent subjects

Luis SAN, JORDI CAMÍ, TERESA FERNÁNDEZ, JOSÉ M. OLLÉ, JOSÉ M. PERI, MARTA TORRENS

Research output: Contribution to journal › Article › Research › peer-review

46 Citations (Scopus)

Abstract

The spontaneous physical dependence of buprenorphine was assessed in opioid addicts who switched from heroin to sublingual or intravenous buprenorphine. Twenty‐two patients were randomly assigned to double‐blind administration of methadone (n = 11) or placebo (n=11) for 13 days after abrupt withdrawal of buprenorphine. Methadone was administered according to four pre‐established dosing schedules depending on the previous amount of daily consumed buprenorphine. No methadone‐treated patient required modification of the therapeutic regimen, whereas eight of eleven placebo‐treated patients needed treatment with methadone. Buprenorphine withdrawal syndrome was of opioid type, began somewhat more slowly, and showed a peak until day 5. The occurrence, time‐course and characteristics of buprenorphine withdrawal syndrome make it necessary to reconsider the abuse potential of this analgesic. Copyright © 1992, Wiley Blackwell. All rights reserved

Original language	English
Pages (from-to)	55-62
Journal	British Journal of Addiction
Volume	87
Issue number	1
DOIs	https://doi.org/10.1111/j.1360-0443.1992.tb01900.x
Publication status	Published - 1 Jan 1992

Access to Document

10.1111/j.1360-0443.1992.tb01900.x

Cite this

@article{daa408052d4f4786be6724675cb55a0a,

title = "Assessment and management of opioid withdrawal symptoms in buprenorphine‐dependent subjects",

abstract = "The spontaneous physical dependence of buprenorphine was assessed in opioid addicts who switched from heroin to sublingual or intravenous buprenorphine. Twenty‐two patients were randomly assigned to double‐blind administration of methadone (n = 11) or placebo (n=11) for 13 days after abrupt withdrawal of buprenorphine. Methadone was administered according to four pre‐established dosing schedules depending on the previous amount of daily consumed buprenorphine. No methadone‐treated patient required modification of the therapeutic regimen, whereas eight of eleven placebo‐treated patients needed treatment with methadone. Buprenorphine withdrawal syndrome was of opioid type, began somewhat more slowly, and showed a peak until day 5. The occurrence, time‐course and characteristics of buprenorphine withdrawal syndrome make it necessary to reconsider the abuse potential of this analgesic. Copyright {\textcopyright} 1992, Wiley Blackwell. All rights reserved",

author = "Luis SAN and JORDI CAM{\'I} and TERESA FERN{\'A}NDEZ and OLL{\'E}, {JOS{\'E} M.} and PERI, {JOS{\'E} M.} and MARTA TORRENS",

year = "1992",

month = jan,

day = "1",

doi = "10.1111/j.1360-0443.1992.tb01900.x",

language = "English",

volume = "87",

pages = "55--62",

number = "1",

}

TY - JOUR

T1 - Assessment and management of opioid withdrawal symptoms in buprenorphine‐dependent subjects

AU - SAN, Luis

AU - CAMÍ, JORDI

AU - FERNÁNDEZ, TERESA

AU - OLLÉ, JOSÉ M.

AU - PERI, JOSÉ M.

AU - TORRENS, MARTA

PY - 1992/1/1

Y1 - 1992/1/1

N2 - The spontaneous physical dependence of buprenorphine was assessed in opioid addicts who switched from heroin to sublingual or intravenous buprenorphine. Twenty‐two patients were randomly assigned to double‐blind administration of methadone (n = 11) or placebo (n=11) for 13 days after abrupt withdrawal of buprenorphine. Methadone was administered according to four pre‐established dosing schedules depending on the previous amount of daily consumed buprenorphine. No methadone‐treated patient required modification of the therapeutic regimen, whereas eight of eleven placebo‐treated patients needed treatment with methadone. Buprenorphine withdrawal syndrome was of opioid type, began somewhat more slowly, and showed a peak until day 5. The occurrence, time‐course and characteristics of buprenorphine withdrawal syndrome make it necessary to reconsider the abuse potential of this analgesic. Copyright © 1992, Wiley Blackwell. All rights reserved

AB - The spontaneous physical dependence of buprenorphine was assessed in opioid addicts who switched from heroin to sublingual or intravenous buprenorphine. Twenty‐two patients were randomly assigned to double‐blind administration of methadone (n = 11) or placebo (n=11) for 13 days after abrupt withdrawal of buprenorphine. Methadone was administered according to four pre‐established dosing schedules depending on the previous amount of daily consumed buprenorphine. No methadone‐treated patient required modification of the therapeutic regimen, whereas eight of eleven placebo‐treated patients needed treatment with methadone. Buprenorphine withdrawal syndrome was of opioid type, began somewhat more slowly, and showed a peak until day 5. The occurrence, time‐course and characteristics of buprenorphine withdrawal syndrome make it necessary to reconsider the abuse potential of this analgesic. Copyright © 1992, Wiley Blackwell. All rights reserved

U2 - 10.1111/j.1360-0443.1992.tb01900.x

DO - 10.1111/j.1360-0443.1992.tb01900.x

M3 - Article

VL - 87

SP - 55

EP - 62

IS - 1

ER -

Assessment and management of opioid withdrawal symptoms in buprenorphine‐dependent subjects

Abstract

Access to Document

Fingerprint

Cite this