Assessment and management of opioid withdrawal symptoms in buprenorphine‐dependent subjects

Luis SAN, JORDI CAMÍ, TERESA FERNÁNDEZ, JOSÉ M. OLLÉ, JOSÉ M. PERI, MARTA TORRENS

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    Abstract

    The spontaneous physical dependence of buprenorphine was assessed in opioid addicts who switched from heroin to sublingual or intravenous buprenorphine. Twenty‐two patients were randomly assigned to double‐blind administration of methadone (n = 11) or placebo (n=11) for 13 days after abrupt withdrawal of buprenorphine. Methadone was administered according to four pre‐established dosing schedules depending on the previous amount of daily consumed buprenorphine. No methadone‐treated patient required modification of the therapeutic regimen, whereas eight of eleven placebo‐treated patients needed treatment with methadone. Buprenorphine withdrawal syndrome was of opioid type, began somewhat more slowly, and showed a peak until day 5. The occurrence, time‐course and characteristics of buprenorphine withdrawal syndrome make it necessary to reconsider the abuse potential of this analgesic. Copyright © 1992, Wiley Blackwell. All rights reserved
    Original languageEnglish
    Pages (from-to)55-62
    JournalBritish Journal of Addiction
    Volume87
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 1992

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    SAN, L., CAMÍ, JORDI., FERNÁNDEZ, TERESA., OLLÉ, JOSÉ. M., PERI, JOSÉ. M., & TORRENS, MARTA. (1992). Assessment and management of opioid withdrawal symptoms in buprenorphine‐dependent subjects. British Journal of Addiction, 87(1), 55-62. https://doi.org/10.1111/j.1360-0443.1992.tb01900.x