ASS234, as a new multi-target directed propargylamine for Alzheimer's disease therapy

José Marco-Contelles, Mercedes Unzeta, Irene Bolea, Gerard Esteban, Rona R. Ramsay, Alejandro Romero, Ricard Martínez-Murillo, M. Carmo Carreiras, Lhassane Ismaili

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37 Citations (Scopus)


© 2016 Marco-Contelles, Unzeta, Bolea, Esteban, Ramsay, Romero, Martínez-Murillo, Carreiras and Ismaili. The complex nature of Alzheimer's disease (AD) has prompted the design of Multi-Target-Directed Ligands (MTDL) able to bind to diverse biochemical targets involved in the progress and development of the disease. In this context, we have designed a number of MTD propargylamines (MTDP) showing antioxidant, anti-beta-amyloid, anti-inflammatory, as well as cholinesterase and monoamine oxidase (MAO) inhibition capacities. Here, we describe these properties in the MTDL ASS234, our lead-compound ready to enter in pre-clinical studies for AD, as a new multipotent, permeable cholinesterase/monoamine oxidase inhibitor, able to inhibit Aß-aggregation, and possessing antioxidant and neuroprotective properties.
Original languageEnglish
Article number294
JournalFrontiers in Neuroscience
Issue numberJUN
Publication statusPublished - 28 Jun 2016


  • Alzheimer's disease
  • Cholinesterases
  • Drugs
  • Monoamine oxidases
  • Multi-target directed ligands

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