Arsenic Biosensors: Challenges and Opportunities for High-Throughput Detection

Minni Singh, Manel del Valle

    Research output: Chapter in BookChapterResearchpeer-review

    3 Citations (Scopus)

    Abstract

    © 2015 Elsevier Inc. All rights reserved. A detailed overview of arsenic biosensors and advancements is presented with particular emphasis on recombinant whole-cell-based biosensors employing engineered plasmid constructs with the inherent ars operon in cells as the basis of biorecognition. The review discusses the need for the development of rapid, sensitive, and accurate analysis of arsenic due to its widespread toxicity. New approaches for arsenic detection using nanosensor platforms as next generation biorecognition elements are detailed, suggesting their role in high-throughput detection. Though their use for arsenic biosensing is in its infancy and their precision in on-site detection is yet to be established, the capability of aptamer-graphene nanoensembles to augment conventional detection methods to be considered as reference points of action for risk assessments is proposed.
    Original languageEnglish
    Title of host publicationHandbook of Arsenic Toxicology
    Pages575-588
    Number of pages13
    DOIs
    Publication statusPublished - 8 Jan 2015

    Keywords

    • Aptamer
    • Arsenic
    • Biosensor
    • Electrochemical
    • Graphene
    • Nanobiosensor
    • Optical
    • Recombinants

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