Are patients with bipolar disorder and comorbid attention-deficit hyperactivity disorder more neurocognitively impaired?

Imma Torres, Brisa Sole, Montse Corrales, Esther Jiménez, Sofia Rotger, Juan Francisco Serra-Pla, Irene Forcada, Vanesa Richarte, Ester Mora, Carlos Jacas, Nuria Gómez, Maria Mur, Francesc Colom, Eduard Vieta, Miquel Casas, Anabel Martinez-Aran, Jose M. Goikolea, Josep A. Ramos-Quiroga

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)


© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Objective: Research on neurocognitive impairment in adult patients with comorbid bipolar disorder (BD) and attention-deficit hyperactivity disorder (ADHD) is very scarce. This study assessed the neurocognitive profile of a comorbid group (BD+ADHD) compared with that of pure BD (pBD) group, pure ADHD (pADHD) group and healthy controls (HCs). Methods: This was a three-site study comprising 229 subjects: 70 patients with pBD, 23 with BD+ADHD, 50 with pADHD, and 86 HCs. All patients with BD had been euthymic for at least 6 months. Neuropsychological performance was assessed using a comprehensive neurocognitive battery. Results: Our results showed that all the clinical groups had poorer performance than the HCs in all the neurocognitive domains except for executive functions. No significant differences were observed between the pBD and BD+ADHD groups in any of the cognitive domains, with these two groups showing greater impairment than the pADHD group in executive functions and visual memory. Conclusions: Our results, although preliminary, suggest that the BD+ADHD group showed the same neurocognitive profile as pBD patients, most likely reflecting the same neurobiological basis. On the other hand, the pADHD group showed a more selective moderate impairment in attention.
Original languageEnglish
Pages (from-to)637-650
JournalBipolar Disorders
Issue number8
Publication statusPublished - 1 Dec 2017


  • attention-deficit hyperactivity disorder
  • bipolar disorder
  • comorbidity and neurocognition


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