Are anti-beta 2-glycoprotein-I antibodies markers for recurrent pregnancy loss in lupus Anticoagulant/Anticardiolipin Seronegative Women?

Problem: Anti-beta2-Glicoprotein-1 antibodies (anti-β 2 GPI-ab) have been related to recurrent miscarriage (RM) with conflicting results. The aim was to evaluate the role of anti-β 2 -GPI-ab as unique biological marker in RM related to antiphospholipid (aPL). Method of study: A cohort study that included 59 cases, divided in two groups, was designed: group 1 comprised 43 pregnant women with 'obstetric' antiphospholipid syndrome (APS) and group 2 included 16 cases with similar complaints but only having repeatedly anti-β 2-GPI-ab. Previous thrombosis and/or inherited thrombophilia were excluded. Lupus anticoagulant, anticardiolipin antibodies (aCA), anti-β 2-GPI-ab, and other autoantibodies were analyzed. Miscarriages, premature births, pre-eclampsia, live births, placental and systemic thromboses were studied. Results: No differences in previous obstetric complications were detected (P=1.00-0.164). After the treatment, differences in number of obstetric complications were not seen (P=1.00). Live births were similar in two groups (88.4% and 93.7%; P=1.00). Placental thrombosis was equal in both groups, 93.3% versus 80% (P=1.00). Conclusion: These results suggest that anti-β 2-GPI-ab may be considered a biological marker for obstetric APS. © Journal compilation © 2008 Blackwell Munksgaard.