Are anti-beta 2-glycoprotein-I antibodies markers for recurrent pregnancy loss in lupus Anticoagulant/Anticardiolipin Seronegative Women?

Jaume Alijotas-Reig, Manel Casellas-Caro, Raquel Ferrer-Oliveras, Elisa Llurba-Olive, Eduard Hermosilla, Miquel Vilardell-Tarres, Lluis Cabero-Roura

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15 Citations (Scopus)

Abstract

Problem: Anti-beta2-Glicoprotein-1 antibodies (anti-β 2 GPI-ab) have been related to recurrent miscarriage (RM) with conflicting results. The aim was to evaluate the role of anti-β 2 -GPI-ab as unique biological marker in RM related to antiphospholipid (aPL). Method of study: A cohort study that included 59 cases, divided in two groups, was designed: group 1 comprised 43 pregnant women with 'obstetric' antiphospholipid syndrome (APS) and group 2 included 16 cases with similar complaints but only having repeatedly anti-β 2-GPI-ab. Previous thrombosis and/or inherited thrombophilia were excluded. Lupus anticoagulant, anticardiolipin antibodies (aCA), anti-β 2-GPI-ab, and other autoantibodies were analyzed. Miscarriages, premature births, pre-eclampsia, live births, placental and systemic thromboses were studied. Results: No differences in previous obstetric complications were detected (P=1.00-0.164). After the treatment, differences in number of obstetric complications were not seen (P=1.00). Live births were similar in two groups (88.4% and 93.7%; P=1.00). Placental thrombosis was equal in both groups, 93.3% versus 80% (P=1.00). Conclusion: These results suggest that anti-β 2-GPI-ab may be considered a biological marker for obstetric APS. © Journal compilation © 2008 Blackwell Munksgaard.
Original languageEnglish
Pages (from-to)229-237
JournalAmerican Journal of Reproductive Immunology
Volume60
Issue number3
DOIs
Publication statusPublished - 29 Aug 2008

Keywords

  • Anti-β GPI antibodies 2
  • Anti-cofactor syndrome
  • Antiphospholipid antibodies
  • Antiphospholipid syndrome
  • Recurrent miscarriage
  • Treatment

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