Apo(B)-dependent dyslipidemic phenotypes in type 1 diabetic patients

Ana Marı́a Wägner, Jordi Ordóñez-Llanos, Marta Hernández, Jose Luis Sánchez-Quesada, Francisco Blanco-Vaca, Mercedes Rigla, Alberto de Leiva, Antonio Pérez

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Background: The prevalence of apo(B)-dependent dyslipidemic phenotypes, which are associated with cardiovascular disease, is increased in normocholesterolemic type 2 diabetic patients. Our aim was to determine the impact of including apo(B) in the evaluation of normocholesterolemic type 1 diabetic patients. Methods: A total of 123 type 1 diabetic patients (47% male, age 36.6±12.5 years) were included. The apo(B) cut-off point (1.14 g/l) was obtained from a group of 53 normolipidemic control subjects of similar age and gender distribution; for low density lipoprotein cholesterol (LDLc), triglycerides, and high density lipoprotein cholesterol (HDLc), we used the cut-off points recommended by the National Cholesterol Education Program. LDLc was determined by ultracentrifugation or Friedewald's equation, depending on triglyceride concentrations, and apo(B) by immunoturbidimetry. Results: A total of 113 (92%) type 1 diabetic patients were normocholesterolemic, and 13% of these were dyslipidemic. The frequency of hyperapo(B) was similar in normocholesterolemic patients and controls (6.2 vs. 9.4%, respectively). Diabetic patients with hyperapo(B) had poorer glycemic control, higher total cholesterol, triglycerides, and LDLc, and a lower HDLc and LDLc/apo(B) ratio. Conclusions: Unlike type 2 diabetes, type 1 diabetes is not associated with an increased prevalence of hyperapo(B)-dependent dyslipidemic phenotypes. Thus, only in patients with poor glycemic control who display other components of diabetic dyslipidemia, typical for type 2 diabetes, does determining apo(B) concentrations provide additional information in type 1 diabetes. © 2001 Published by Elsevier Science B.V.
Original languageEnglish
Pages (from-to)496-502
JournalEuropean Journal of Internal Medicine
Issue number6
Publication statusPublished - 1 Jan 2001


  • Apolipoprotein (B)
  • Diabetic dyslipidemia
  • Hyperapo(B)lipoproteinemia
  • Insulin-dependent diabetes mellitus


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