Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment

Joaquín Sastre; Astrid Crespo; Antonio Fernandez-Sanchez; Manuel Rial; Vicente Plaza; F. Callejas González; J. Jiménez López; M. Martínez Riaza; M. Moscardó Orenes; P. Prieto Montaño; M. Torrecillas Toro; C. Andreu Balaguer; M. Antón Girones; C. Baeza Martinez; I. Flores Martín; P. Gonzalez Delgado; M. Martos Calahorro; G. Mediero Carrasco; R. Rodríguez Pacheco; V. Vilella Tomás; M. Mota Godoy; J. Zapata Yébenes; O. Villarreal Balza De Vallejo; J. Alvarez Fernandez; T. Bazus Gonzalez; G. Castaño De Las Pozas; C. Diaz Donado; S. Díaz Angulo; G. Gala Ortiz; B. Requejo Mañana; R. Blanco Gonzalez; E. Gómez Nieves; J. Marin Torrado; M. Dordal Culla; J. Juanola Pla; R. Lleonart Bellfill; J. Martos Velasco; E. Pinto Nogues; M. Rivera Ortun; P. Rubinstein Aguñin; N. Subira Farre; J. Valldeperas Combas; I. Ansotegui Zubeldia; G. Bernaola Hortigüela; J. Ciruelos Ayuso; G. González Álvarez; M. Herrerias Peña; A. Lahuerta Castro; P. Losada Llorente; P. Marin Martinez; N. Marina Malanda; F. Garcia Gonzalez; T. Peña Miguel; M. Hernandez; S. Jimenez Timon; S. Porcel Carreño; M. Alwakil Olbah; A. Arnedillo Muñoz; J. Chamorro Mohedad; D. Gutierrez Fernandez; A. Letran Camacho; C. Merinas Lopez; M. Millan Gonzalez; S. Niño Bernal; L. Fernandez Pellon; E. Morchon Miguel; F. Ortiz Portal; A. Suárez Rodríguez; M. Modesto Alapont; I. Raducan; M. Salvador Segarra; P. Galindo Bonilla; P. Mata Calderon; M. Mena Rodriguez; R. Lama Martinez; M. Martín Pérez; M. Morales Villarejo; M. Blanco Aparicio; M. Do Muíño Joga; L. Fontan Garcia-Boente; V. García Paz; F. Gonzalez Barcala; R. Nuñez Orjales; C. Rabade Castedo; M. Rico Diaz; A. Moreno Fernandez; S. Aparicio Español; A. Ruiz San Francisco; B. Alcázar Navarrete; L. Cassini Gomez De Cadiz; M. Escribano Rodriguez; J. Florido Lopez; M. Lara Jiménez; J. Lopez Caballero; M. Martínez Ceres; R. Mayorgas Costoya; C. Morales García; M. Rojas Vilchez; A. Romero Ortiz; J. Beitia Mazuecos

doi:10.1016/j.jaip.2018.02.002

Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment

Joaquín Sastre, Astrid Crespo, Antonio Fernandez-Sanchez, Manuel Rial, Vicente Plaza, F. Callejas González, J. Jiménez López, M. Martínez Riaza, M. Moscardó Orenes, P. Prieto Montaño, M. Torrecillas Toro, C. Andreu Balaguer, M. Antón Girones, C. Baeza Martinez, I. Flores Martín, P. Gonzalez Delgado, M. Martos Calahorro, G. Mediero Carrasco, R. Rodríguez Pacheco, V. Vilella TomásM. Mota Godoy, J. Zapata Yébenes, O. Villarreal Balza De Vallejo, J. Alvarez Fernandez, T. Bazus Gonzalez, G. Castaño De Las Pozas, C. Diaz Donado, S. Díaz Angulo, G. Gala Ortiz, B. Requejo Mañana, R. Blanco Gonzalez, E. Gómez Nieves, J. Marin Torrado, M. Dordal Culla, J. Juanola Pla, R. Lleonart Bellfill, J. Martos Velasco, E. Pinto Nogues, M. Rivera Ortun, P. Rubinstein Aguñin, N. Subira Farre, J. Valldeperas Combas, I. Ansotegui Zubeldia, G. Bernaola Hortigüela, J. Ciruelos Ayuso, G. González Álvarez, M. Herrerias Peña, A. Lahuerta Castro, P. Losada Llorente, P. Marin Martinez, N. Marina Malanda, F. Garcia Gonzalez, T. Peña Miguel, M. Hernandez, S. Jimenez Timon, S. Porcel Carreño, M. Alwakil Olbah, A. Arnedillo Muñoz, J. Chamorro Mohedad, D. Gutierrez Fernandez, A. Letran Camacho, C. Merinas Lopez, M. Millan Gonzalez, S. Niño Bernal, L. Fernandez Pellon, E. Morchon Miguel, F. Ortiz Portal, A. Suárez Rodríguez, M. Modesto Alapont, I. Raducan, M. Salvador Segarra, P. Galindo Bonilla, P. Mata Calderon, M. Mena Rodriguez, R. Lama Martinez, M. Martín Pérez, M. Morales Villarejo, M. Blanco Aparicio, M. Do Muíño Joga, L. Fontan Garcia-Boente, V. García Paz, F. Gonzalez Barcala, R. Nuñez Orjales, C. Rabade Castedo, M. Rico Diaz, A. Moreno Fernandez, S. Aparicio Español, A. Ruiz San Francisco, B. Alcázar Navarrete, L. Cassini Gomez De Cadiz, M. Escribano Rodriguez, J. Florido Lopez, M. Lara Jiménez, J. Lopez Caballero, M. Martínez Ceres, R. Mayorgas Costoya, C. Morales García, M. Rojas Vilchez, A. Romero Ortiz, J. Beitia Mazuecos

Department of Medicine

Research output: Contribution to journal › Article › Research

22 Citations (Scopus)

Abstract

© 2018 American Academy of Allergy, Asthma & Immunology Background: It has been documented that anxiety and depression are prevalent in patients with asthma and are associated with greater frequency of exacerbations, increased use of health care resources, and poor asthma control. Objective: To examine the association of asthma diagnosis with symptoms of depression/anxiety and asthma control not only at baseline but also over a 6-month period of specialist supervision. Methods: We enrolled 3182 patients with moderate to severe asthma. All were evaluated with spirometry, the Asthma Control Test, and the Hospital Anxiety and Depression Scale at baseline and at 6 months. Treatments were decided by specialists according to published guidelines. Results: At baseline, 24.2% and 12% of the patients were diagnosed with anxiety and depression, respectively, according to the Hospital Anxiety and Depression Scale. After 6 months, anxiety and depression improved, affecting 15.3% and 8.1% of patients, respectively (P <.001); mean FEV1 and asthma control also improved (FEV1 from 81.6% ± 20.9% to 86% ± 20.8%; Asthma Control Test score from 15.8 ± 4.7 to 19.4 ± 4.4; both P <.001). Patients with anxiety and depression used significantly more health care resources and had more exacerbations. A multivariate analysis showed that patients with anxiety, depression, and lower FEV1 (odds ratio, 0.20, 0.34, 0.62, respectively; P <.001) were independently associated with poor asthma control. A multiple linear regression analysis showed that anxiety had a nearly 4-fold greater influence over asthma control than depression (0.326/0.85 = 4.075). Conclusion: Under standardized asthma care and after a specific visit with the specialist, patients present significant improvement in these psychological disorders and exhibit better asthma control and functional parameters.

Original language	English
Pages (from-to)	1953-1959
Journal	Journal of Allergy and Clinical Immunology: In Practice
Volume	6
DOIs	https://doi.org/10.1016/j.jaip.2018.02.002
Publication status	Published - 1 Nov 2018

Keywords

Anxiety
Asthma
Asthma control
Asthma exacerbations
Depression
Health care resources

Access to Document

10.1016/j.jaip.2018.02.002

Cite this

Sastre, J., Crespo, A., Fernandez-Sanchez, A., Rial, M., Plaza, V., González, F. C., López, J. J., Riaza, M. M., Orenes, M. M., Montaño, P. P., Toro, M. T., Balaguer, C. A., Girones, M. A., Martinez, C. B., Martín, I. F., Delgado, P. G., Calahorro, M. M., Carrasco, G. M., Pacheco, R. R., ... Mazuecos, J. B. (2018). Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment. Journal of Allergy and Clinical Immunology: In Practice, 6, 1953-1959. https://doi.org/10.1016/j.jaip.2018.02.002

Sastre, Joaquín ; Crespo, Astrid ; Fernandez-Sanchez, Antonio ; Rial, Manuel ; Plaza, Vicente ; González, F. Callejas ; López, J. Jiménez ; Riaza, M. Martínez ; Orenes, M. Moscardó ; Montaño, P. Prieto ; Toro, M. Torrecillas ; Balaguer, C. Andreu ; Girones, M. Antón ; Martinez, C. Baeza ; Martín, I. Flores ; Delgado, P. Gonzalez ; Calahorro, M. Martos ; Carrasco, G. Mediero ; Pacheco, R. Rodríguez ; Tomás, V. Vilella ; Godoy, M. Mota ; Yébenes, J. Zapata ; Balza De Vallejo, O. Villarreal ; Fernandez, J. Alvarez ; Gonzalez, T. Bazus ; De Las Pozas, G. Castaño ; Donado, C. Diaz ; Angulo, S. Díaz ; Ortiz, G. Gala ; Mañana, B. Requejo ; Gonzalez, R. Blanco ; Nieves, E. Gómez ; Torrado, J. Marin ; Culla, M. Dordal ; Pla, J. Juanola ; Bellfill, R. Lleonart ; Velasco, J. Martos ; Nogues, E. Pinto ; Ortun, M. Rivera ; Aguñin, P. Rubinstein ; Farre, N. Subira ; Combas, J. Valldeperas ; Zubeldia, I. Ansotegui ; Hortigüela, G. Bernaola ; Ayuso, J. Ciruelos ; Álvarez, G. González ; Peña, M. Herrerias ; Castro, A. Lahuerta ; Llorente, P. Losada ; Martinez, P. Marin ; Malanda, N. Marina ; Gonzalez, F. Garcia ; Miguel, T. Peña ; Hernandez, M. ; Timon, S. Jimenez ; Carreño, S. Porcel ; Olbah, M. Alwakil ; Muñoz, A. Arnedillo ; Mohedad, J. Chamorro ; Fernandez, D. Gutierrez ; Camacho, A. Letran ; Lopez, C. Merinas ; Gonzalez, M. Millan ; Bernal, S. Niño ; Pellon, L. Fernandez ; Miguel, E. Morchon ; Portal, F. Ortiz ; Rodríguez, A. Suárez ; Alapont, M. Modesto ; Raducan, I. ; Segarra, M. Salvador ; Bonilla, P. Galindo ; Calderon, P. Mata ; Rodriguez, M. Mena ; Martinez, R. Lama ; Pérez, M. Martín ; Villarejo, M. Morales ; Aparicio, M. Blanco ; Muíño Joga, M. Do ; Garcia-Boente, L. Fontan ; Paz, V. García ; Barcala, F. Gonzalez ; Orjales, R. Nuñez ; Castedo, C. Rabade ; Diaz, M. Rico ; Fernandez, A. Moreno ; Español, S. Aparicio ; San Francisco, A. Ruiz ; Navarrete, B. Alcázar ; Gomez De Cadiz, L. Cassini ; Rodriguez, M. Escribano ; Lopez, J. Florido ; Jiménez, M. Lara ; Caballero, J. Lopez ; Ceres, M. Martínez ; Costoya, R. Mayorgas ; García, C. Morales ; Vilchez, M. Rojas ; Ortiz, A. Romero ; Mazuecos, J. Beitia. / Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment. In: Journal of Allergy and Clinical Immunology: In Practice. 2018 ; Vol. 6. pp. 1953-1959.

@article{34453b7e91214b4e9b8fa16e1ab6f1f2,

title = "Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment",

abstract = "{\textcopyright} 2018 American Academy of Allergy, Asthma & Immunology Background: It has been documented that anxiety and depression are prevalent in patients with asthma and are associated with greater frequency of exacerbations, increased use of health care resources, and poor asthma control. Objective: To examine the association of asthma diagnosis with symptoms of depression/anxiety and asthma control not only at baseline but also over a 6-month period of specialist supervision. Methods: We enrolled 3182 patients with moderate to severe asthma. All were evaluated with spirometry, the Asthma Control Test, and the Hospital Anxiety and Depression Scale at baseline and at 6 months. Treatments were decided by specialists according to published guidelines. Results: At baseline, 24.2% and 12% of the patients were diagnosed with anxiety and depression, respectively, according to the Hospital Anxiety and Depression Scale. After 6 months, anxiety and depression improved, affecting 15.3% and 8.1% of patients, respectively (P <.001); mean FEV1 and asthma control also improved (FEV1 from 81.6% ± 20.9% to 86% ± 20.8%; Asthma Control Test score from 15.8 ± 4.7 to 19.4 ± 4.4; both P <.001). Patients with anxiety and depression used significantly more health care resources and had more exacerbations. A multivariate analysis showed that patients with anxiety, depression, and lower FEV1 (odds ratio, 0.20, 0.34, 0.62, respectively; P <.001) were independently associated with poor asthma control. A multiple linear regression analysis showed that anxiety had a nearly 4-fold greater influence over asthma control than depression (0.326/0.85 = 4.075). Conclusion: Under standardized asthma care and after a specific visit with the specialist, patients present significant improvement in these psychological disorders and exhibit better asthma control and functional parameters.",

keywords = "Anxiety, Asthma, Asthma control, Asthma exacerbations, Depression, Health care resources",

author = "Joaqu{\'i}n Sastre and Astrid Crespo and Antonio Fernandez-Sanchez and Manuel Rial and Vicente Plaza and Gonz{\'a}lez, {F. Callejas} and L{\'o}pez, {J. Jim{\'e}nez} and Riaza, {M. Mart{\'i}nez} and Orenes, {M. Moscard{\'o}} and Monta{\~n}o, {P. Prieto} and Toro, {M. Torrecillas} and Balaguer, {C. Andreu} and Girones, {M. Ant{\'o}n} and Martinez, {C. Baeza} and Mart{\'i}n, {I. Flores} and Delgado, {P. Gonzalez} and Calahorro, {M. Martos} and Carrasco, {G. Mediero} and Pacheco, {R. Rodr{\'i}guez} and Tom{\'a}s, {V. Vilella} and Godoy, {M. Mota} and Y{\'e}benes, {J. Zapata} and {Balza De Vallejo}, {O. Villarreal} and Fernandez, {J. Alvarez} and Gonzalez, {T. Bazus} and {De Las Pozas}, {G. Casta{\~n}o} and Donado, {C. Diaz} and Angulo, {S. D{\'i}az} and Ortiz, {G. Gala} and Ma{\~n}ana, {B. Requejo} and Gonzalez, {R. Blanco} and Nieves, {E. G{\'o}mez} and Torrado, {J. Marin} and Culla, {M. Dordal} and Pla, {J. Juanola} and Bellfill, {R. Lleonart} and Velasco, {J. Martos} and Nogues, {E. Pinto} and Ortun, {M. Rivera} and Agu{\~n}in, {P. Rubinstein} and Farre, {N. Subira} and Combas, {J. Valldeperas} and Zubeldia, {I. Ansotegui} and Hortig{\"u}ela, {G. Bernaola} and Ayuso, {J. Ciruelos} and {\'A}lvarez, {G. Gonz{\'a}lez} and Pe{\~n}a, {M. Herrerias} and Castro, {A. Lahuerta} and Llorente, {P. Losada} and Martinez, {P. Marin} and Malanda, {N. Marina} and Gonzalez, {F. Garcia} and Miguel, {T. Pe{\~n}a} and M. Hernandez and Timon, {S. Jimenez} and Carre{\~n}o, {S. Porcel} and Olbah, {M. Alwakil} and Mu{\~n}oz, {A. Arnedillo} and Mohedad, {J. Chamorro} and Fernandez, {D. Gutierrez} and Camacho, {A. Letran} and Lopez, {C. Merinas} and Gonzalez, {M. Millan} and Bernal, {S. Ni{\~n}o} and Pellon, {L. Fernandez} and Miguel, {E. Morchon} and Portal, {F. Ortiz} and Rodr{\'i}guez, {A. Su{\'a}rez} and Alapont, {M. Modesto} and I. Raducan and Segarra, {M. Salvador} and Bonilla, {P. Galindo} and Calderon, {P. Mata} and Rodriguez, {M. Mena} and Martinez, {R. Lama} and P{\'e}rez, {M. Mart{\'i}n} and Villarejo, {M. Morales} and Aparicio, {M. Blanco} and {Mu{\'i}{\~n}o Joga}, {M. Do} and Garcia-Boente, {L. Fontan} and Paz, {V. Garc{\'i}a} and Barcala, {F. Gonzalez} and Orjales, {R. Nu{\~n}ez} and Castedo, {C. Rabade} and Diaz, {M. Rico} and Fernandez, {A. Moreno} and Espa{\~n}ol, {S. Aparicio} and {San Francisco}, {A. Ruiz} and Navarrete, {B. Alc{\'a}zar} and {Gomez De Cadiz}, {L. Cassini} and Rodriguez, {M. Escribano} and Lopez, {J. Florido} and Jim{\'e}nez, {M. Lara} and Caballero, {J. Lopez} and Ceres, {M. Mart{\'i}nez} and Costoya, {R. Mayorgas} and Garc{\'i}a, {C. Morales} and Vilchez, {M. Rojas} and Ortiz, {A. Romero} and Mazuecos, {J. Beitia}",

year = "2018",

month = nov,

day = "1",

doi = "10.1016/j.jaip.2018.02.002",

language = "English",

volume = "6",

pages = "1953--1959",

journal = "Journal of Allergy and Clinical Immunology: In Practice",

issn = "2213-2198",

}

Sastre, J, Crespo, A, Fernandez-Sanchez, A, Rial, M, Plaza, V, González, FC, López, JJ, Riaza, MM, Orenes, MM, Montaño, PP, Toro, MT, Balaguer, CA, Girones, MA, Martinez, CB, Martín, IF, Delgado, PG, Calahorro, MM, Carrasco, GM, Pacheco, RR, Tomás, VV, Godoy, MM, Yébenes, JZ, Balza De Vallejo, OV, Fernandez, JA, Gonzalez, TB, De Las Pozas, GC, Donado, CD, Angulo, SD, Ortiz, GG, Mañana, BR, Gonzalez, RB, Nieves, EG, Torrado, JM, Culla, MD, Pla, JJ, Bellfill, RL, Velasco, JM, Nogues, EP, Ortun, MR, Aguñin, PR, Farre, NS, Combas, JV, Zubeldia, IA, Hortigüela, GB, Ayuso, JC, Álvarez, GG, Peña, MH, Castro, AL, Llorente, PL, Martinez, PM, Malanda, NM, Gonzalez, FG, Miguel, TP, Hernandez, M, Timon, SJ, Carreño, SP, Olbah, MA, Muñoz, AA, Mohedad, JC, Fernandez, DG, Camacho, AL, Lopez, CM, Gonzalez, MM, Bernal, SN, Pellon, LF, Miguel, EM, Portal, FO, Rodríguez, AS, Alapont, MM, Raducan, I, Segarra, MS, Bonilla, PG, Calderon, PM, Rodriguez, MM, Martinez, RL, Pérez, MM, Villarejo, MM, Aparicio, MB, Muíño Joga, MD, Garcia-Boente, LF, Paz, VG, Barcala, FG, Orjales, RN, Castedo, CR, Diaz, MR, Fernandez, AM, Español, SA, San Francisco, AR, Navarrete, BA, Gomez De Cadiz, LC, Rodriguez, ME, Lopez, JF, Jiménez, ML, Caballero, JL, Ceres, MM, Costoya, RM, García, CM, Vilchez, MR, Ortiz, AR & Mazuecos, JB 2018, 'Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment', Journal of Allergy and Clinical Immunology: In Practice, vol. 6, pp. 1953-1959. https://doi.org/10.1016/j.jaip.2018.02.002

Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment. / Sastre, Joaquín; Crespo, Astrid; Fernandez-Sanchez, Antonio; Rial, Manuel; Plaza, Vicente; González, F. Callejas; López, J. Jiménez; Riaza, M. Martínez; Orenes, M. Moscardó; Montaño, P. Prieto; Toro, M. Torrecillas; Balaguer, C. Andreu; Girones, M. Antón; Martinez, C. Baeza; Martín, I. Flores; Delgado, P. Gonzalez; Calahorro, M. Martos; Carrasco, G. Mediero; Pacheco, R. Rodríguez; Tomás, V. Vilella; Godoy, M. Mota; Yébenes, J. Zapata; Balza De Vallejo, O. Villarreal; Fernandez, J. Alvarez; Gonzalez, T. Bazus; De Las Pozas, G. Castaño; Donado, C. Diaz; Angulo, S. Díaz; Ortiz, G. Gala; Mañana, B. Requejo; Gonzalez, R. Blanco; Nieves, E. Gómez; Torrado, J. Marin; Culla, M. Dordal; Pla, J. Juanola; Bellfill, R. Lleonart; Velasco, J. Martos; Nogues, E. Pinto; Ortun, M. Rivera; Aguñin, P. Rubinstein; Farre, N. Subira; Combas, J. Valldeperas; Zubeldia, I. Ansotegui; Hortigüela, G. Bernaola; Ayuso, J. Ciruelos; Álvarez, G. González; Peña, M. Herrerias; Castro, A. Lahuerta; Llorente, P. Losada; Martinez, P. Marin; Malanda, N. Marina; Gonzalez, F. Garcia; Miguel, T. Peña; Hernandez, M.; Timon, S. Jimenez; Carreño, S. Porcel; Olbah, M. Alwakil; Muñoz, A. Arnedillo; Mohedad, J. Chamorro; Fernandez, D. Gutierrez; Camacho, A. Letran; Lopez, C. Merinas; Gonzalez, M. Millan; Bernal, S. Niño; Pellon, L. Fernandez; Miguel, E. Morchon; Portal, F. Ortiz; Rodríguez, A. Suárez; Alapont, M. Modesto; Raducan, I.; Segarra, M. Salvador; Bonilla, P. Galindo; Calderon, P. Mata; Rodriguez, M. Mena; Martinez, R. Lama; Pérez, M. Martín; Villarejo, M. Morales; Aparicio, M. Blanco; Muíño Joga, M. Do; Garcia-Boente, L. Fontan; Paz, V. García; Barcala, F. Gonzalez; Orjales, R. Nuñez; Castedo, C. Rabade; Diaz, M. Rico; Fernandez, A. Moreno; Español, S. Aparicio; San Francisco, A. Ruiz; Navarrete, B. Alcázar; Gomez De Cadiz, L. Cassini; Rodriguez, M. Escribano; Lopez, J. Florido; Jiménez, M. Lara; Caballero, J. Lopez; Ceres, M. Martínez; Costoya, R. Mayorgas; García, C. Morales; Vilchez, M. Rojas; Ortiz, A. Romero; Mazuecos, J. Beitia.

In: Journal of Allergy and Clinical Immunology: In Practice, Vol. 6, 01.11.2018, p. 1953-1959.

Research output: Contribution to journal › Article › Research

TY - JOUR

T1 - Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment

AU - Sastre, Joaquín

AU - Crespo, Astrid

AU - Fernandez-Sanchez, Antonio

AU - Rial, Manuel

AU - Plaza, Vicente

AU - González, F. Callejas

AU - López, J. Jiménez

AU - Riaza, M. Martínez

AU - Orenes, M. Moscardó

AU - Montaño, P. Prieto

AU - Toro, M. Torrecillas

AU - Balaguer, C. Andreu

AU - Girones, M. Antón

AU - Martinez, C. Baeza

AU - Martín, I. Flores

AU - Delgado, P. Gonzalez

AU - Calahorro, M. Martos

AU - Carrasco, G. Mediero

AU - Pacheco, R. Rodríguez

AU - Tomás, V. Vilella

AU - Godoy, M. Mota

AU - Yébenes, J. Zapata

AU - Balza De Vallejo, O. Villarreal

AU - Fernandez, J. Alvarez

AU - Gonzalez, T. Bazus

AU - De Las Pozas, G. Castaño

AU - Donado, C. Diaz

AU - Angulo, S. Díaz

AU - Ortiz, G. Gala

AU - Mañana, B. Requejo

AU - Gonzalez, R. Blanco

AU - Nieves, E. Gómez

AU - Torrado, J. Marin

AU - Culla, M. Dordal

AU - Pla, J. Juanola

AU - Bellfill, R. Lleonart

AU - Velasco, J. Martos

AU - Nogues, E. Pinto

AU - Ortun, M. Rivera

AU - Aguñin, P. Rubinstein

AU - Farre, N. Subira

AU - Combas, J. Valldeperas

AU - Zubeldia, I. Ansotegui

AU - Hortigüela, G. Bernaola

AU - Ayuso, J. Ciruelos

AU - Álvarez, G. González

AU - Peña, M. Herrerias

AU - Castro, A. Lahuerta

AU - Llorente, P. Losada

AU - Martinez, P. Marin

AU - Malanda, N. Marina

AU - Gonzalez, F. Garcia

AU - Miguel, T. Peña

AU - Hernandez, M.

AU - Timon, S. Jimenez

AU - Carreño, S. Porcel

AU - Olbah, M. Alwakil

AU - Muñoz, A. Arnedillo

AU - Mohedad, J. Chamorro

AU - Fernandez, D. Gutierrez

AU - Camacho, A. Letran

AU - Lopez, C. Merinas

AU - Gonzalez, M. Millan

AU - Bernal, S. Niño

AU - Pellon, L. Fernandez

AU - Miguel, E. Morchon

AU - Portal, F. Ortiz

AU - Rodríguez, A. Suárez

AU - Alapont, M. Modesto

AU - Raducan, I.

AU - Segarra, M. Salvador

AU - Bonilla, P. Galindo

AU - Calderon, P. Mata

AU - Rodriguez, M. Mena

AU - Martinez, R. Lama

AU - Pérez, M. Martín

AU - Villarejo, M. Morales

AU - Aparicio, M. Blanco

AU - Muíño Joga, M. Do

AU - Garcia-Boente, L. Fontan

AU - Paz, V. García

AU - Barcala, F. Gonzalez

AU - Orjales, R. Nuñez

AU - Castedo, C. Rabade

AU - Diaz, M. Rico

AU - Fernandez, A. Moreno

AU - Español, S. Aparicio

AU - San Francisco, A. Ruiz

AU - Navarrete, B. Alcázar

AU - Gomez De Cadiz, L. Cassini

AU - Rodriguez, M. Escribano

AU - Lopez, J. Florido

AU - Jiménez, M. Lara

AU - Caballero, J. Lopez

AU - Ceres, M. Martínez

AU - Costoya, R. Mayorgas

AU - García, C. Morales

AU - Vilchez, M. Rojas

AU - Ortiz, A. Romero

AU - Mazuecos, J. Beitia

PY - 2018/11/1

Y1 - 2018/11/1

N2 - © 2018 American Academy of Allergy, Asthma & Immunology Background: It has been documented that anxiety and depression are prevalent in patients with asthma and are associated with greater frequency of exacerbations, increased use of health care resources, and poor asthma control. Objective: To examine the association of asthma diagnosis with symptoms of depression/anxiety and asthma control not only at baseline but also over a 6-month period of specialist supervision. Methods: We enrolled 3182 patients with moderate to severe asthma. All were evaluated with spirometry, the Asthma Control Test, and the Hospital Anxiety and Depression Scale at baseline and at 6 months. Treatments were decided by specialists according to published guidelines. Results: At baseline, 24.2% and 12% of the patients were diagnosed with anxiety and depression, respectively, according to the Hospital Anxiety and Depression Scale. After 6 months, anxiety and depression improved, affecting 15.3% and 8.1% of patients, respectively (P <.001); mean FEV1 and asthma control also improved (FEV1 from 81.6% ± 20.9% to 86% ± 20.8%; Asthma Control Test score from 15.8 ± 4.7 to 19.4 ± 4.4; both P <.001). Patients with anxiety and depression used significantly more health care resources and had more exacerbations. A multivariate analysis showed that patients with anxiety, depression, and lower FEV1 (odds ratio, 0.20, 0.34, 0.62, respectively; P <.001) were independently associated with poor asthma control. A multiple linear regression analysis showed that anxiety had a nearly 4-fold greater influence over asthma control than depression (0.326/0.85 = 4.075). Conclusion: Under standardized asthma care and after a specific visit with the specialist, patients present significant improvement in these psychological disorders and exhibit better asthma control and functional parameters.

AB - © 2018 American Academy of Allergy, Asthma & Immunology Background: It has been documented that anxiety and depression are prevalent in patients with asthma and are associated with greater frequency of exacerbations, increased use of health care resources, and poor asthma control. Objective: To examine the association of asthma diagnosis with symptoms of depression/anxiety and asthma control not only at baseline but also over a 6-month period of specialist supervision. Methods: We enrolled 3182 patients with moderate to severe asthma. All were evaluated with spirometry, the Asthma Control Test, and the Hospital Anxiety and Depression Scale at baseline and at 6 months. Treatments were decided by specialists according to published guidelines. Results: At baseline, 24.2% and 12% of the patients were diagnosed with anxiety and depression, respectively, according to the Hospital Anxiety and Depression Scale. After 6 months, anxiety and depression improved, affecting 15.3% and 8.1% of patients, respectively (P <.001); mean FEV1 and asthma control also improved (FEV1 from 81.6% ± 20.9% to 86% ± 20.8%; Asthma Control Test score from 15.8 ± 4.7 to 19.4 ± 4.4; both P <.001). Patients with anxiety and depression used significantly more health care resources and had more exacerbations. A multivariate analysis showed that patients with anxiety, depression, and lower FEV1 (odds ratio, 0.20, 0.34, 0.62, respectively; P <.001) were independently associated with poor asthma control. A multiple linear regression analysis showed that anxiety had a nearly 4-fold greater influence over asthma control than depression (0.326/0.85 = 4.075). Conclusion: Under standardized asthma care and after a specific visit with the specialist, patients present significant improvement in these psychological disorders and exhibit better asthma control and functional parameters.

KW - Anxiety

KW - Asthma

KW - Asthma control

KW - Asthma exacerbations

KW - Depression

KW - Health care resources

U2 - 10.1016/j.jaip.2018.02.002

DO - 10.1016/j.jaip.2018.02.002

M3 - Article

C2 - 29454162

VL - 6

SP - 1953

EP - 1959

JO - Journal of Allergy and Clinical Immunology: In Practice

JF - Journal of Allergy and Clinical Immunology: In Practice

SN - 2213-2198

ER -

Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment

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