Antimutagenic mechanisms of Phyllanthus orbicularis when hydrogen peroxide is tested using Salmonella assay

Mirle Ferrer, Angel Sánchez-Lamar, Jorge Luís Fuentes, Jordi Barbé, Montserrat Llagostera

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Abstract

Phyllanthus orbicularis is a medicinal plant, endemic to Cuba, whose aqueous extract has proven antiviral properties and antimutagenic activities against aromatic amines and hydrogen peroxide. In addition, this plant extract presents antioxidant activity. In this paper, using the Salmonella assay with the experimental approaches of co-incubation, pre- and post-treatments, it is shown that the P. orbicularis extract protects bacterial cells from oxidative damage and mutation by some intracellular mechanism, irrespective of its antioxidant activity. © 2002 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)251-254
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume517
Issue number1-2
DOIs
Publication statusPublished - 27 May 2002

Keywords

  • Antimutagenesis
  • Oxidative agents
  • P. orbicularis
  • Protective effect

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