Antimicrobial susceptibility of bacterial isolates from urinary tract infections in companion animals in Spain

Laila Darwich, Chiara Seminati, Ares Burballa, Alba Nieto, Inma Durán, Núria Tarradas, Rafael A Molina-López

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

BACKGROUND: The increasing emergence of multidrug-resistant bacteria, causing urinary tract infections (UTI) in dogs and cats, represents a great therapeutic challenge and a public health concern.

METHODS: Laboratory records of 4943 urinary microbiological diagnosis results and antimicrobial resistance profiles of suspected UTI cases in dogs and cats were analysed from 2016 to 2018 in Spain.

RESULTS: This study showed a higher percentage of positive microbiological diagnoses in dogs (42%, 1368/3270) than in cats (27%, 457/1673). Although Escherichia coli was the most frequently isolated bacterium, the frequency of antimicrobial susceptibility of E. coli isolates was lower compared to other bacterial species like Enterococcus spp., Staphylococcus spp., Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter (E. cloacae), and Proteus mirabilis. The antimicrobial susceptibility testing of Gram-positive cocci showed higher levels of resistance in cats to common beta-lactams used for the treatment of complicated UTIs, as well as to fluoroquinolones, aminoglycosides, and carbapenems. Moreover, enterobacteria (E. coli, K. pneumoniae, and P. mirabilis) from cats presented high resistance frequencies to beta-lactams, including third- and fourth-generation cephalosporins and fluoroquinolones.

CONCLUSION: This study updates data on the current antimicrobial resistance in UTI bacteria from companion animals in Spain, which may help to guide clinicians for the appropriate use of antimicrobials.

Original languageEnglish
Pages (from-to)no
JournalThe Veterinary record
Volume188
Issue number9
DOIs
Publication statusPublished - 28 Jan 2021

Keywords

  • Animals
  • Anti-Bacterial Agents/pharmacology
  • Bacteria/drug effects
  • Bacterial Infections/drug therapy
  • Cat Diseases/drug therapy
  • Cats
  • Dog Diseases/drug therapy
  • Dogs
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Male
  • Pets
  • Spain
  • Urinary Tract Infections/drug therapy
  • antimicrobial resistance
  • urinary tract infections
  • companion animals

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