TY - JOUR
T1 - Antimicrobial defined daily dose adjusted by weight: a proposal for antibiotic consumption measurement in children
AU - Montecatine-Alonso, Elena
AU - Gil-Navarro, María Victoria
AU - Fernández-Llamazares, Cecilia M.
AU - Fernández-Polo, Aurora
AU - Soler-Palacín, Pere
AU - Llorente-Gutiérrez, Jesús
AU - Gómez-Travecedo Calvo, María Teresa
AU - Esquivel-Mora, María Dolores
AU - Pérez-Rodrigo, Icíar
AU - Cisneros, José M.
AU - Goycochea-Valdivia, Walter Alfredo
AU - Neth, Olaf
PY - 2019/5/1
Y1 - 2019/5/1
N2 - © 2018 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica Introduction: Antimicrobial defined daily dose (DDD), has limitations for antimicrobial consumption measurement in paediatrics. An alternative DDD design applicable for children is proposed. Methods: Children (<16 years-old) from 10 Spanish hospitals during a 12-months period were included. Weight for age (50th percentile) was calculated for the median age of the cohort using standardized World Health Organization tables. DDD (g) for each antimicrobial was calculated by multiplying the obtained weight times the recommended dose (mg/kg) of the antimicrobial for the most common infectious indication. Results: A total of 40,575 children were included. Median age was 4.17 (IQR: 1.36–8.98) and 4.81 (IQR: 1.42–9.60) years for boys and girls, respectively. Mean weight for this age was 17.08 kg. Standardized DDD for representative antimicrobials were calculated. Conclusions: A useful method for antimicrobial DDD measurement in paediatrics has been proposed and should be validated in future studies for its use in paediatric antimicrobial stewardship programmes.
AB - © 2018 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica Introduction: Antimicrobial defined daily dose (DDD), has limitations for antimicrobial consumption measurement in paediatrics. An alternative DDD design applicable for children is proposed. Methods: Children (<16 years-old) from 10 Spanish hospitals during a 12-months period were included. Weight for age (50th percentile) was calculated for the median age of the cohort using standardized World Health Organization tables. DDD (g) for each antimicrobial was calculated by multiplying the obtained weight times the recommended dose (mg/kg) of the antimicrobial for the most common infectious indication. Results: A total of 40,575 children were included. Median age was 4.17 (IQR: 1.36–8.98) and 4.81 (IQR: 1.42–9.60) years for boys and girls, respectively. Mean weight for this age was 17.08 kg. Standardized DDD for representative antimicrobials were calculated. Conclusions: A useful method for antimicrobial DDD measurement in paediatrics has been proposed and should be validated in future studies for its use in paediatric antimicrobial stewardship programmes.
KW - Antibiotic prescription
KW - Antibiotic usage
KW - Antimicrobial management
KW - Paediatrics
U2 - 10.1016/j.eimc.2018.07.011
DO - 10.1016/j.eimc.2018.07.011
M3 - Article
C2 - 30268590
SN - 0213-005X
VL - 37
SP - 301
EP - 306
JO - Enfermedades Infecciosas y Microbiologia Clinica
JF - Enfermedades Infecciosas y Microbiologia Clinica
ER -