Antihypertensive effect of manidipine

Alex Roca-Cusachs, Filippos Triposkiadis

Research output: Contribution to journalReview articleResearchpeer-review

10 Citations (Scopus)


Manidipine is a lipophilic, third-generation, highly vasoselective, dihydropyridine (DHP) calcium channel antagonist, which, when given on a once-daily basis, effectively reduces blood pressure (BP) in patients with mild-to-moderate essential hypertension. Manidipine has a gradual onset and a long duration of action, effectively maintaining reduced BP levels throughout the 24-hour dosing period, and is effective in the long term with no evidence of intolerance. The BP-lowering capacity of manidipine is similar to that of other established DHPs and of angiotensin-converting enzyme inhibitors. Diabetic patients and very elderly patients with mild-to-moderate hypertension also respond favourably to treatment with manidipine. Manidipine has neutral effects on glucose and lipid metabolism and is generally well tolerated. Manidipine thus represents a first-line option for lowering BP in patients with mild-to-moderate hypertension. © 2005 Adis Data Information BV. All rights reserved.
Original languageEnglish
Pages (from-to)11-19
Issue numberSUPPL. 2
Publication statusPublished - 27 Oct 2005


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