TY - JOUR
T1 - Antibiotic resistance genes in the bacteriophage DNA fraction of human fecal samples
AU - Quirós, Pablo
AU - Colomer-Lluch, Marta
AU - Martínez-Castillo, Alexandre
AU - Miró, Elisenda
AU - Argente, Marc
AU - Jofre, Juan
AU - Navarro, Ferran
AU - Muniesa, Maite
PY - 2014/1
Y1 - 2014/1
N2 - A group of antibiotic resistance genes (ARGs) (blaTEM, bla CTX-M-1, mecA, armA, qnrA, and qnrS) were analyzed by real-time quantitative PCR (qPCR) in bacteriophage DNA isolated from feces from 80 healthy humans. Seventy-seven percent of the samples were positive in phage DNA for one or more ARGs. blaTEM, qnrA, and, blaCTX-M-1 were the most abundant, and armA, qnrS, and mecA were less prevalent. Free bacteriophages carrying ARGs may contribute to the mobilization of ARGs in intra- and extraintestinal environments.
AB - A group of antibiotic resistance genes (ARGs) (blaTEM, bla CTX-M-1, mecA, armA, qnrA, and qnrS) were analyzed by real-time quantitative PCR (qPCR) in bacteriophage DNA isolated from feces from 80 healthy humans. Seventy-seven percent of the samples were positive in phage DNA for one or more ARGs. blaTEM, qnrA, and, blaCTX-M-1 were the most abundant, and armA, qnrS, and mecA were less prevalent. Free bacteriophages carrying ARGs may contribute to the mobilization of ARGs in intra- and extraintestinal environments.
UR - http://www.scopus.com/inward/record.url?scp=84891501192&partnerID=8YFLogxK
U2 - 10.1128/AAC.01684-13
DO - 10.1128/AAC.01684-13
M3 - Article
C2 - 24165177
AN - SCOPUS:84891501192
SN - 0066-4804
VL - 58
SP - 606
EP - 609
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 1
ER -
