TY - JOUR
T1 - Antibacterial activity of novel benzopolycyclic amines
AU - Barniol-Xicota, Marta
AU - Escandell, Alex
AU - Valverde, Elena
AU - Julián, Esther
AU - Torrents, Eduard
AU - Vázquez, Santiago
PY - 2015/1/15
Y1 - 2015/1/15
N2 - © 2014 Elsevier Ltd. All rights reserved. Staphylococcus aureus, especially strains resistant to multiple antibiotics, is a major pathogen for humans and animals. In this paper we have synthesized and evaluated the antibacterial activity of a new series of benzopolycyclic amines. Some of them exhibited μM MIC values against Staphylococcus aureus and other bacteria, including methicillin-resistant S. aureus MRSA. Compound 8 that displayed a good selectivity index, showed to be active in eliminating bacterial cells forming a preexisting biofilm.
AB - © 2014 Elsevier Ltd. All rights reserved. Staphylococcus aureus, especially strains resistant to multiple antibiotics, is a major pathogen for humans and animals. In this paper we have synthesized and evaluated the antibacterial activity of a new series of benzopolycyclic amines. Some of them exhibited μM MIC values against Staphylococcus aureus and other bacteria, including methicillin-resistant S. aureus MRSA. Compound 8 that displayed a good selectivity index, showed to be active in eliminating bacterial cells forming a preexisting biofilm.
KW - Antibacterials
KW - Minimal biofilm inhibitory concentration
KW - Polycyclic compounds
KW - Staphylococcus aureus
U2 - https://doi.org/10.1016/j.bmc.2014.11.041
DO - https://doi.org/10.1016/j.bmc.2014.11.041
M3 - Article
SN - 0968-0896
VL - 23
SP - 290
EP - 296
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
ER -