Antibacterial activity of novel benzopolycyclic amines

Marta Barniol-Xicota, Alex Escandell, Elena Valverde, Esther Julián, Eduard Torrents, Santiago Vázquez

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

© 2014 Elsevier Ltd. All rights reserved. Staphylococcus aureus, especially strains resistant to multiple antibiotics, is a major pathogen for humans and animals. In this paper we have synthesized and evaluated the antibacterial activity of a new series of benzopolycyclic amines. Some of them exhibited μM MIC values against Staphylococcus aureus and other bacteria, including methicillin-resistant S. aureus MRSA. Compound 8 that displayed a good selectivity index, showed to be active in eliminating bacterial cells forming a preexisting biofilm.
Original languageEnglish
Pages (from-to)290-296
JournalBioorganic and Medicinal Chemistry
Volume23
DOIs
Publication statusPublished - 15 Jan 2015

Keywords

  • Antibacterials
  • Minimal biofilm inhibitory concentration
  • Polycyclic compounds
  • Staphylococcus aureus

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