TY - JOUR
T1 - Anti-Ro/SSA antibodies and cardiac rhythm disturbances: Present and future perspectives
AU - Santos-Pardo, Irene
AU - Villuendas, Roger
AU - Salvador-Corres, Iñaki
AU - Martínez-Morillo, Melania
AU - Olivé, Alejandro
AU - Bayes-Genis, Antoni
PY - 2015/1/1
Y1 - 2015/1/1
N2 - © 2014 Published by Elsevier Ireland Ltd. Several case reports, small case series, and original research papers have recently suggested that the action of certain auto-antibodies related to connective tissue diseases may be responsible for significant cardiac rhythm disturbances in adults. The relationship between anti-Ro/SSA antibodies and congenital complete atrioventricular block iswell recognizedinthe fetal heart. Herein we review the emerging evidences of the link to increased levels of anti-Ro/SSA antibodies with rhythm disorders of unknown originin the adult. Confirmation of this distinct etiology may eventually be the basis for new therapies.
AB - © 2014 Published by Elsevier Ireland Ltd. Several case reports, small case series, and original research papers have recently suggested that the action of certain auto-antibodies related to connective tissue diseases may be responsible for significant cardiac rhythm disturbances in adults. The relationship between anti-Ro/SSA antibodies and congenital complete atrioventricular block iswell recognizedinthe fetal heart. Herein we review the emerging evidences of the link to increased levels of anti-Ro/SSA antibodies with rhythm disorders of unknown originin the adult. Confirmation of this distinct etiology may eventually be the basis for new therapies.
KW - Anti-Ro/SSA
KW - Cardiac rhythm disturbances
KW - Pathogenesis
U2 - 10.1016/j.ijcard.2014.11.002
DO - 10.1016/j.ijcard.2014.11.002
M3 - Review article
SN - 0167-5273
VL - 184
SP - 244
EP - 250
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 1
ER -