Anti-myelin antibodies play an important role in the susceptibility to develop proteolipid protein-induced experimental autoimmune encephalomyelitis

N. Marín, H. Eixarch, M. J. Mansilla, E. Rodríguez-Martín, M. Mecha, C. Guaza, J. C. Álvarez-Cermeño, X. Montalban, L. M. Villar, C. Espejo

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5 Citations (Scopus)

Abstract

Summary: Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. It is an autoimmune disorder in which activated T cells cross the blood-brain barrier (BBB) to initiate an inflammatory response that leads to demyelination and axonal damage. The key mechanisms responsible for disease initiation are still unknown. We addressed this issue in experimental autoimmune encephalomyelitis (EAE), the animal model of MS. It is widely known that EAE manifests only in certain strains when immunized with myelin proteins or peptides. We studied the differential immune responses induced in two mouse strains that are susceptible or resistant to EAE induction when they are immunized with the 139-151 peptide of proteolipid protein, an encephalitogenic peptide capable of inducing EAE in the susceptible strain. The adequate combination of major histocompatibility complex alleles and myelin peptides triggered in susceptible mice a T helper type 17 (Th17) response capable of inducing the production of high-affinity anti-myelin immunoglobulin (Ig)G antibodies. These were not detected in resistant mice, despite immunization with the encephalitogenic peptide in junction with complete Freund's adjuvant and pertussis toxin, which mediate BBB disruption. These data show the pivotal role of Th17 responses and of high-affinity anti-myelin antibodies in EAE induction and that mechanisms that prevent their appearance can contribute to resistance to EAE. © 2013 British Society for Immunology.
Original languageEnglish
Pages (from-to)202-207
JournalClinical and Experimental Immunology
Volume175
Issue number2
DOIs
Publication statusPublished - 1 Feb 2014

Keywords

  • Anti-myelin antibodies
  • Experimental autoimmune encephalomyelitis
  • Immune response
  • Multiple sclerosis

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