TY - JOUR
T1 - Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: A randomized, crossover, controlled trial
AU - Fitó, M.
AU - Cladellas, M.
AU - de la Torre, R.
AU - Martí, J.
AU - Muñoz, D.
AU - Schröder, H.
AU - Alcántara, M.
AU - Pujadas-Bastardes, M.
AU - Marrugat, J.
AU - Ló-Sabater, M. C.
AU - Bruguera, J.
AU - Covas, M. I.
PY - 2008/8/12
Y1 - 2008/8/12
N2 - Objectives: To assess the effect of two similar olive oils, but with differences in their phenolic compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary heart disease patients. Design: Placebo-controlled, crossover, randomized trial. Setting: Cardiology Department of Hospital del Mar and Institut Municipal d'Investigació Mèdica (Barcelona). Subjects: Twenty-eight stable coronary heart disease patients. Interventions: A raw daily dose of 50 ml of virgin and refined olive oil (ROO) was sequentially administered over two periods of 3-weeks, preceded by 2-week washout periods in which ROO was used. Results: Interleukin-6 (P < 0.002) and C-reactive protein (P = 0.024) decreased after virgin olive oil intervention. No changes were observed in soluble intercellular and vascular adhesion molecules, glucose and lipid profile. Conclusions: Consumption of virgin olive oil, could provide beneficial effects in stable coronary heart disease patients as an additional intervention to the pharmacological treatment.
AB - Objectives: To assess the effect of two similar olive oils, but with differences in their phenolic compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary heart disease patients. Design: Placebo-controlled, crossover, randomized trial. Setting: Cardiology Department of Hospital del Mar and Institut Municipal d'Investigació Mèdica (Barcelona). Subjects: Twenty-eight stable coronary heart disease patients. Interventions: A raw daily dose of 50 ml of virgin and refined olive oil (ROO) was sequentially administered over two periods of 3-weeks, preceded by 2-week washout periods in which ROO was used. Results: Interleukin-6 (P < 0.002) and C-reactive protein (P = 0.024) decreased after virgin olive oil intervention. No changes were observed in soluble intercellular and vascular adhesion molecules, glucose and lipid profile. Conclusions: Consumption of virgin olive oil, could provide beneficial effects in stable coronary heart disease patients as an additional intervention to the pharmacological treatment.
U2 - https://doi.org/10.1038/sj.ejcn.1602724
DO - https://doi.org/10.1038/sj.ejcn.1602724
M3 - Article
SN - 0954-3007
VL - 62
SP - 570
EP - 574
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
ER -