Anti-inflammatory and sedative activities of Peperomia galioides: in vivo studies in mice

Isabel Wilches, Priscila Jiménez-Castillo, Nancy Cuzco, M. Victoria Clos, Francesc Jiménez-Altayó, Eugenia Peñaherrera, Lourdes Jerves-Andrade, Vladimiro Tobar, Yvan Vander Heyden, Fabián Leon-Tamariz, Elisabet Vila

Research output: Contribution to journalArticleResearch

1 Citation (Scopus)


© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Aerial parts (leaves, flowers, stem) of Peperomia galioides extract administered to mice, was used to confirm its anti-inflammatory and sedative folk uses. The anti-inflammatory activity was assessed by croton oil-induced ear oedema and myeloperoxidase (acute inflammation); cotton pellet-induced granuloma (sub-acute inflammation) and Escherichia coli Lipopolysaccharide (LPS) induced inflammation (cellular mediators). The sedative activity was studied by the pentobarbital-induced sleeping time test. Single doses (300 and 600 mg/kg; i.p.) of the extract reduced croton oil-induced ear oedema and myeloperoxidase activity. Six days administration of the extract (300 mg/kg, i.p.) to mice implanted with cotton pellets diminished granuloma formation. LPS (20 mg/kg, i.p.) enhanced plasma nitrites and TNF-α levels that were inhibited by the extract. The duration but not the onset of sleeping time was enhanced by 300 and 600 mg/kg of the extract. Our results show that P. galioides has anti-inflammatory and sedative activities in mice, which validates its traditional use.
Original languageEnglish
JournalNatural Product Research
Publication statusPublished - 1 Jan 2019


  • anti-inflammatory
  • mice models
  • Peperomia galioides
  • sedative activity


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