Anti-inflammatory activity of piroxicam after oral and topical administration on an ultraviolet-induced erythema model in man

J. Torrent, I. Izquierdo, M. J. Barbanoj, J. Moreno, J. Lauroba, F. Jane

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    5 Citations (Scopus)

    Abstract

    The efficacy of piroxicam administered both topically (1% cream) and after a single oral dose of 20 mg (capsules) compared with a placebo vehicle was evaluated using a standardized ultraviolet-induced erythema model. The study was carried out with six normal healthy subjects, a double-blind, double-dummy, crossover design with randomized assignment of treatments to the irradiated areas. Subjects received oral piroxicam or placebo and the corresponding topical formulation with a one-week interval between each session. Anti-inflammatory effects were evaluated by measuring the erythema area after ultraviolet-injury on different sites of the subject's back at 4, 6, 7, 8 and 24 hours post-irradiation. The results showed that both active treatments reduced the erythema size. However, the topical application produced a significantly higher inhibition of the irradiated surface, over eight hours, than the oral treatment.
    Original languageEnglish
    Pages (from-to)340-347
    JournalCurrent Therapeutic Research - Clinical and Experimental
    Volume44
    Issue number2
    Publication statusPublished - 1 Jan 1988

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