Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw

Asunción Romero, Eulalia Planas, Raquel Poveda, Silvia Sánchez, Olga Pol, Margarita M. Puig*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Abstract

We evaluated the anti-exudative effects (Evan's blue) of mu-, delta- and kappa-opioid receptor agonists in a rat model of carrageenan-induced acute inflammation. The contribution of different components was assessed after the administration of: cyclosporine A, capsaicin, 6-hydroxydopamine, compound 48/80, and specific histamine-receptor antagonists. The results show that the mu-opioid receptor agonists morphine and fentanyl and the delta-opioid receptor agonists DPDPE (enkephalin, [d-Pen2,5]) and SNC 80 ((+)-4-[(αR)-α((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl) -3-methoxybenzyl]-N,N diethylbenzamide) decrease plasma extravasation in a dose-dependent manner, with a biphasic response. The effects were reversed by specific antagonists, and are predominantly mediated by peripheral opioid receptors. The integrity of sensory and sympathetic fibres is essential for the anti-exudative effects of fentanyl and DPDPE. Histamine and functional histamine H2 and H3 receptors are required for morphine and fentanyl (but not DPDPE) inhibition of plasma extravasation, suggesting different mechanism for mu- and delta-opioid receptor agonists. The present findings implicate multiple sites and mechanisms in the anti-exudative effects of exogenous opioids.

Original languageAmerican English
Pages (from-to)207-217
Number of pages11
JournalEuropean Journal of Pharmacology
Volume511
Issue number2-3
DOIs
Publication statusPublished - 28 Mar 2005

Keywords

  • Histamine
  • Inflammation
  • Oedema
  • Opioid receptor
  • Plasma extravasation

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