Anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with idiopathic inflammatory myopathy

Moisés Labrador-Horrillo, Ma Angeles Martinez, Albert Selva-O'Callaghan, Juan Francisco Delgado, Xavier Martínez-Gómez, Ernesto Trallero-Araguás, Jose Luis Rodriguez-Sanchez, Miquel Vilardell-Tarrés

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16 Citations (Scopus)


Objective. To investigate the prevalence of anti-cyclic citrullinated peptide (anti-CCP) and anti-keratin antibodies (AKAs) in a cohort of patients with idiopathic inflammatory myopathy. Methods. In a cross-sectional study, we determined the presence of anti-CCP and AKAs by ELISA and IIF, respectively, in a cohort of 90 consecutive patients with idiopathic inflammatory myopathy. Associations between anti-CCP and clinical manifestations or other autoantibodies were determined with the chi-square and Mann-Whitney U-tests. Radiographs of hands were retrospectively evaluated. Serum autoantibody profile was determined in all patients. Results. Twelve patients were positive to anti-CCP (13.3%); in eight cases values were moderate-high. AKAs were not detected in any patient. Comparison between patients positive and negative to anti-CCP did not show clinical or biological differences. Arthritis joint erosions or positive status to anti-synthetase antibodies were not more frequent in patients with anti-CCP antibodies. Prevalence of RF was the only variable significantly associated with the presence of these antibodies (P = 0.043). Conclusions. High titres of anti-CCP can occasionally be found in patients with inflammatory myopathy. Therefore, a possible diagnosis of RA should be considered with caution in these patients. © The Author 2009. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
Original languageEnglish
Pages (from-to)676-679
Issue number6
Publication statusPublished - 29 May 2009


  • Anti-cyclic citrullinated peptide
  • Anti-keratin antibodies
  • Arthritis
  • Autoimmunty
  • Idiopathic inflammatory myopathy
  • Inclusion body myositis
  • Myositis-specific antibodies
  • Polymyositis
  • Rheumatoid arthritis
  • Rheumatoid factor

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