Anomalies produced by cytochalasin B after 10.5 days of gestation: in vitro study

R. M. Mirapeix, J. M. Domenech-Mateu

Research output: Contribution to journalArticleResearchpeer-review

Abstract

124 rats embryos (Rattus Norvegicus sp.) have been cultured for 48 hours period (from 9.5 days to 11.5 days). 24 hours after the beginning of the culture, cytochalasin B (CB) dissolved in 1% dimethylsulphoxide (DMSO) was added to the culture medium in the experimental group (61 embryos), whereas only DMSO was added to the medium in the control group (63 embryos). Survival rate in the control group was 100% whereas in CB-treated embryos the higher the dose, the lesser the survival rate. Embryo growth and morphological score was reduced in CB-treated embryos. The most common gross malformations were delays in axial rotation as well as open neural tube defects.
Original languageEnglish
Pages (from-to)49-51
JournalBulletin de l'Association des anatomistes
Volume76
Issue number233
Publication statusPublished - 1 Jan 1992

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