Animal models for COVID-19

C. Muñoz-Fontela, W.E. Dowling, S.G.P. Funnell, P.-S. Gsell, A.X. Riveros-Balta, R.A. Albrecht, H. Andersen, R.S. Baric, M.W. Carroll, M. Cavaleri, C. Qin, I. Crozier, K. Dallmeier, L. de Waal, E. de Wit, L. Delang, E. Dohm, W.P. Duprex, D. Falzarano, C.L. FinchM.B. Frieman, B.S. Graham, L.E. Gralinski, K. Guilfoyle, B.L. Haagmans, G.A. Hamilton, A.L. Hartman, S. Herfst, S.J.F. Kaptein, W.B. Klimstra, I. Knezevic, P.R. Krause, J.H. Kuhn, R. Le Grand, M.G. Lewis, W.-C. Liu, P. Maisonnasse, A.K. McElroy, V. Munster, N. Oreshkova, A.L. Rasmussen, J. Rocha-Pereira, B. Rockx, E. Rodríguez, T.F. Rogers, F.J. Salguero, M. Schotsaert, K.J. Stittelaar, A. García-Sastre, J. Segalés

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415 Citations (Scopus)


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.
Original languageEnglish
Article number586
Pages (from-to)509-515
Number of pages6
Publication statusPublished - 23 Sept 2020


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