Analysis of Val158Met genotype polymorphisms in the COMT locus and correlation with IL-6 and IL-10 expression in fibromyalgia syndrome

Ferran J. Garcia-Fructuoso, Katrin Beyer, Jose I. Lao-Villadóniga

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    Abstract

    We have determined Val158Met COMT polymorphism genotypes (HH or Val/Val, HL or Val/Met, LL or Met/Met) in 46 fibromyalgia syndrome (FS) patients and 40 controls. A correlation between these alleles and Interleukin-6 (IL-6) and Interleukin-10 (IL-10) expression levels, determined by real-time RT-PCR, has been established. The accumulation of Met-allele carrying genotypes (both heterozygous and homozygous) observed in FS patients revealed an almost 4-fold increase of risk of developing FS. The Met(-) group of FM patients presented significantly increased IL6 expression levels when compared to all other subgroups. Significantly lower IL-10 expression levels were observed in FS patients, especially in those FS cases carrying the Met allele in comparison with FS Met(-) patients and both control groups. © 2006 Informa UK Ltd.
    Original languageEnglish
    Pages (from-to)15-24
    JournalJournal of Drug Assessment
    Volume9
    Issue number1
    Publication statusPublished - 15 May 2006

    Keywords

    • 1L-6
    • COMT polymorphism
    • Fibromyalgia
    • IL-10
    • Metallele

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