Analysis of time-dependent conjugation of gold nanoparticles with an antiparkinsonian molecule by using curve resolution methods

José Manuel Amigo, Neus G. Bastús, Rob Hoen, Socorro Vázquez-Campos, Miriam Varón, Miriam Royo, Victor Puntes

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

In this work, the time-dependent conjugation process between a thiolated molecule (with anti-parkinsonian properties) and gold nanoparticles has been monitored and studied by the combined use of fast acquisition Ultra Violet-Visible (UV-Vis) spectra and the ability of Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) technique. From the highly informative kinetic profiles obtained it was possible to extract quantitative and qualitative information of the conjugation process which includes i) time-dependent concentration profiles and pure spectra of species involved on conjugation process, ii) estimation of molecule concentration necessary for the completeness of the conjugation reaction, iii) molecule footprint and iv) free energy of molecule adsorption. © 2010 Elsevier B.V.
Original languageEnglish
Pages (from-to)170-177
JournalAnalytica Chimica Acta
Volume683
Issue number2
DOIs
Publication statusPublished - 10 Jan 2011

Keywords

  • Adenosine antagonist
  • Gold nanoparticles
  • Kinetic modeling
  • Multivariate Curve Resolution-Alternating Least Squares
  • Ultra Violet-Visible spectroscopy

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