Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis

A. Lopez de Lapuente, I. Alloza, R. Goertsches, U. K. Zettl, E. Urcelay, R. Arroyo, M. Comabella, X. Montalban, A. Antigüedad, K. Vandenbroeck*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)


Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of 2582 cases and 2614 controls. We did not find any consistent association between IL28RA and MS in these populations, suggesting that, although it may play a role in other autoimmune diseases, this gene is unlikely of general relevance to MS pathogenesis.

Original languageEnglish
Pages (from-to)98-101
Number of pages4
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - Apr 2012


  • Interferon-λ
  • Interleukin-28 receptor alpha
  • Multiple sclerosis
  • Polymorphism


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