TY - JOUR
T1 - Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis
AU - Lopez de Lapuente, A.
AU - Alloza, I.
AU - Goertsches, R.
AU - Zettl, U. K.
AU - Urcelay, E.
AU - Arroyo, R.
AU - Comabella, M.
AU - Montalban, X.
AU - Antigüedad, A.
AU - Vandenbroeck, K.
PY - 2012/4
Y1 - 2012/4
N2 - Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of 2582 cases and 2614 controls. We did not find any consistent association between IL28RA and MS in these populations, suggesting that, although it may play a role in other autoimmune diseases, this gene is unlikely of general relevance to MS pathogenesis.
AB - Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of 2582 cases and 2614 controls. We did not find any consistent association between IL28RA and MS in these populations, suggesting that, although it may play a role in other autoimmune diseases, this gene is unlikely of general relevance to MS pathogenesis.
KW - Interferon-λ
KW - Interleukin-28 receptor alpha
KW - Multiple sclerosis
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=84859641473&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2012.02.005
DO - 10.1016/j.jneuroim.2012.02.005
M3 - Article
C2 - 22386267
AN - SCOPUS:84859641473
SN - 0165-5728
VL - 245
SP - 98
EP - 101
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -