Analysis of the IGHV region in Burkitt's lymphomas supports a germinal center origin and a role for superantigens in lymphomagenesis

Maria Joao Baptista; Eva Calpe; Eva Fernandez; Lluis Colomo; Teresa Marta Cardesa-Salzmann; Pau Abrisqueta; Francesc Bosch; Marta Crespo

doi:10.1016/j.leukres.2014.01.001

Analysis of the IGHV region in Burkitt's lymphomas supports a germinal center origin and a role for superantigens in lymphomagenesis

Maria Joao Baptista, Eva Calpe, Eva Fernandez, Lluis Colomo, Teresa Marta Cardesa-Salzmann, Pau Abrisqueta, Francesc Bosch, Marta Crespo

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

The analysis of immunoglobulin heavy chain variable (IGHV) region may disclose the influence of antigens in Burkitt's lymphomas (BL). IGHV sequences from 38 patients and 35 cell lines were analyzed. IGHV3 subset genes were the most used and IGHV4-34 gene was overrepresented. IGHV genes were mutated in 98.6% of the cases, 36% acquired potential glycosylation sites, and in 52% somatic-hypermutation-process was ongoing. Binding motifs for superantigens like Staphylococcal protein A and carbohydrate I/i were preserved in 89% of the cases. IGHV analysis of BL cells supports a germinal center origin and points toward a role for superantigens in lymphomagenesis. © 2014 Elsevier Ltd.

Original language	English
Pages (from-to)	509-515
Journal	Leukemia Research
Volume	38
Issue number	4
DOIs	https://doi.org/10.1016/j.leukres.2014.01.001
Publication status	Published - 1 Jan 2014

Keywords

BL
Glycosylation
IGHV
Intraclonal diversity
SHM
Superantigens

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10.1016/j.leukres.2014.01.001

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title = "Analysis of the IGHV region in Burkitt's lymphomas supports a germinal center origin and a role for superantigens in lymphomagenesis",

abstract = "The analysis of immunoglobulin heavy chain variable (IGHV) region may disclose the influence of antigens in Burkitt's lymphomas (BL). IGHV sequences from 38 patients and 35 cell lines were analyzed. IGHV3 subset genes were the most used and IGHV4-34 gene was overrepresented. IGHV genes were mutated in 98.6% of the cases, 36% acquired potential glycosylation sites, and in 52% somatic-hypermutation-process was ongoing. Binding motifs for superantigens like Staphylococcal protein A and carbohydrate I/i were preserved in 89% of the cases. IGHV analysis of BL cells supports a germinal center origin and points toward a role for superantigens in lymphomagenesis. {\textcopyright} 2014 Elsevier Ltd.",

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author = "Baptista, {Maria Joao} and Eva Calpe and Eva Fernandez and Lluis Colomo and Cardesa-Salzmann, {Teresa Marta} and Pau Abrisqueta and Francesc Bosch and Marta Crespo",

year = "2014",

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doi = "10.1016/j.leukres.2014.01.001",

language = "English",

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journal = "Leukemia Research",

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TY - JOUR

T1 - Analysis of the IGHV region in Burkitt's lymphomas supports a germinal center origin and a role for superantigens in lymphomagenesis

AU - Baptista, Maria Joao

AU - Calpe, Eva

AU - Fernandez, Eva

AU - Colomo, Lluis

AU - Cardesa-Salzmann, Teresa Marta

AU - Abrisqueta, Pau

AU - Bosch, Francesc

AU - Crespo, Marta

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The analysis of immunoglobulin heavy chain variable (IGHV) region may disclose the influence of antigens in Burkitt's lymphomas (BL). IGHV sequences from 38 patients and 35 cell lines were analyzed. IGHV3 subset genes were the most used and IGHV4-34 gene was overrepresented. IGHV genes were mutated in 98.6% of the cases, 36% acquired potential glycosylation sites, and in 52% somatic-hypermutation-process was ongoing. Binding motifs for superantigens like Staphylococcal protein A and carbohydrate I/i were preserved in 89% of the cases. IGHV analysis of BL cells supports a germinal center origin and points toward a role for superantigens in lymphomagenesis. © 2014 Elsevier Ltd.

AB - The analysis of immunoglobulin heavy chain variable (IGHV) region may disclose the influence of antigens in Burkitt's lymphomas (BL). IGHV sequences from 38 patients and 35 cell lines were analyzed. IGHV3 subset genes were the most used and IGHV4-34 gene was overrepresented. IGHV genes were mutated in 98.6% of the cases, 36% acquired potential glycosylation sites, and in 52% somatic-hypermutation-process was ongoing. Binding motifs for superantigens like Staphylococcal protein A and carbohydrate I/i were preserved in 89% of the cases. IGHV analysis of BL cells supports a germinal center origin and points toward a role for superantigens in lymphomagenesis. © 2014 Elsevier Ltd.

KW - BL

KW - Glycosylation

KW - IGHV

KW - Intraclonal diversity

KW - SHM

KW - Superantigens

U2 - 10.1016/j.leukres.2014.01.001

DO - 10.1016/j.leukres.2014.01.001

M3 - Article

SN - 0145-2126

VL - 38

SP - 509

EP - 515

JO - Leukemia Research

JF - Leukemia Research

IS - 4

ER -

Analysis of the IGHV region in Burkitt's lymphomas supports a germinal center origin and a role for superantigens in lymphomagenesis

Abstract

Keywords

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