Analysis of expression of PTEN/PI3 K pathway and programmed cell death ligand 1 (PD-L1) in malignant pleural mesothelioma (MPM)

S. Cedrés, S. Ponce-Aix, N. Pardo-Aranda, A. Navarro-Mendivil, A. Martinez-Marti, J. Zugazagoitia, I. Sansano, M. A. Montoro, A. Enguita, E. Felip

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20 Citations (Scopus)

Abstract

© 2016 Elsevier Ireland Ltd. Background: Malignant pleural mesothelioma (MPM) frequently express elevated AKT/mTOR activity. Previous reports in gliomas, colon, breast and prostate cancer suggest that PTEN/PI3 K pathway may be important for the induction of PD-L1 expression. This study explored the expression of PTEN/PI3 K pathway and PD-L1 in MPM and its relationship with the patient's prognosis. Material and methods: Twenty seven consecutive MPM patients were reviewed. Formalin-fixed, paraffin-embedded tissue biopsies were used for immunohistochemical analysis of PTEN/PI3 K pathway and PD-L1. Results: Expression of PTEN, mTOR, pAKT, p4EBP1, peif4E, pS6 and FOXO3a was found in 88.5%, 92.3%, 78.3%, 38.5%, 100%, 52.2% and 100% of tumors and PD-L1 in 23%. We found a significant correlation between pAKT, FOXO3a and PD-L1 expression and longer overall survival (p < 0.05). We did not identify significant association between the level of PD-L1 expression and alterations in PI3 K pathway. Conclusions: This study shows PTEN/PI3 K pathway and PD-L1 in MPM are frequently activated. Our results suggests that there is not association between PD-L1 and the involvement of the PI3 K pathway in MPM.
Original languageEnglish
Pages (from-to)1-6
JournalLung Cancer
Volume96
DOIs
Publication statusPublished - 1 Jun 2016

Keywords

  • Malignant pleural mesothelioma
  • PD-L1
  • PI3 K
  • Prognostic factor

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