Analysis of 65 pregnancies in 34 women with five different forms of inherited platelet function disorders

Elisa Civaschi; Catherine Klersy; Federica Melazzini; Nuria Pujol-Moix; Cristina Santoro; Marco Cattaneo; Cécile Lavenu-Bombled; Loredana Bury; Pietro Minuz; Paquita Nurden; Ana R. Cid; Adam Cuker; Véronique Latger-Cannard; Remi Favier; Ilaria Nichele; Patrizia Noris

doi:10.1111/bjh.13458

Analysis of 65 pregnancies in 34 women with five different forms of inherited platelet function disorders

Elisa Civaschi, Catherine Klersy, Federica Melazzini, Nuria Pujol-Moix, Cristina Santoro, Marco Cattaneo, Cécile Lavenu-Bombled, Loredana Bury, Pietro Minuz, Paquita Nurden, Ana R. Cid, Adam Cuker, Véronique Latger-Cannard, Remi Favier, Ilaria Nichele, Patrizia Noris

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

28 Citations (Scopus)

Abstract

© 2015 John Wiley & Sons Ltd. This study evaluated 65 pregnancies in 34 women with five different inherited platelet function disorders. Gestation was similar to that of the general population. Severe bleeds requiring blood transfusions were observed in 50% of deliveries in Glanzmann thrombasthenia (GT), but not in the patients with delta storage pool disease, Hermansky-Pudlak syndrome, P2Y12 defect or defect of thromboxane A2 receptor. Of note, severe haemorrhage also occurred in women with GT who had received prophylactic platelet transfusions, suggesting that better preventive treatments are required. Diagnosis and degree of spontaneous bleeding tendency before pregnancy were reliable parameters to predict the delivery-related bleeding risk.

Original language	English
Pages (from-to)	559-563
Journal	British Journal of Haematology
Volume	170
Issue number	4
DOIs	https://doi.org/10.1111/bjh.13458
Publication status	Published - 1 Jan 2015

Keywords

Bleeding diathesis
Bleeding risk
Inherited platelet disorders
Perinatal haemostasis
Pregnancy

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10.1111/bjh.13458

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Civaschi, E., Klersy, C., Melazzini, F., Pujol-Moix, N., Santoro, C., Cattaneo, M., Lavenu-Bombled, C., Bury, L., Minuz, P., Nurden, P., Cid, A. R., Cuker, A., Latger-Cannard, V., Favier, R., Nichele, I., & Noris, P. (2015). Analysis of 65 pregnancies in 34 women with five different forms of inherited platelet function disorders. British Journal of Haematology, 170(4), 559-563. https://doi.org/10.1111/bjh.13458

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abstract = "{\textcopyright} 2015 John Wiley & Sons Ltd. This study evaluated 65 pregnancies in 34 women with five different inherited platelet function disorders. Gestation was similar to that of the general population. Severe bleeds requiring blood transfusions were observed in 50% of deliveries in Glanzmann thrombasthenia (GT), but not in the patients with delta storage pool disease, Hermansky-Pudlak syndrome, P2Y12 defect or defect of thromboxane A2 receptor. Of note, severe haemorrhage also occurred in women with GT who had received prophylactic platelet transfusions, suggesting that better preventive treatments are required. Diagnosis and degree of spontaneous bleeding tendency before pregnancy were reliable parameters to predict the delivery-related bleeding risk.",

keywords = "Bleeding diathesis, Bleeding risk, Inherited platelet disorders, Perinatal haemostasis, Pregnancy",

author = "Elisa Civaschi and Catherine Klersy and Federica Melazzini and Nuria Pujol-Moix and Cristina Santoro and Marco Cattaneo and C{\'e}cile Lavenu-Bombled and Loredana Bury and Pietro Minuz and Paquita Nurden and Cid, {Ana R.} and Adam Cuker and V{\'e}ronique Latger-Cannard and Remi Favier and Ilaria Nichele and Patrizia Noris",

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Civaschi, E, Klersy, C, Melazzini, F, Pujol-Moix, N, Santoro, C, Cattaneo, M, Lavenu-Bombled, C, Bury, L, Minuz, P, Nurden, P, Cid, AR, Cuker, A, Latger-Cannard, V, Favier, R, Nichele, I & Noris, P 2015, 'Analysis of 65 pregnancies in 34 women with five different forms of inherited platelet function disorders', British Journal of Haematology, vol. 170, no. 4, pp. 559-563. https://doi.org/10.1111/bjh.13458

TY - JOUR

T1 - Analysis of 65 pregnancies in 34 women with five different forms of inherited platelet function disorders

AU - Civaschi, Elisa

AU - Klersy, Catherine

AU - Melazzini, Federica

AU - Pujol-Moix, Nuria

AU - Santoro, Cristina

AU - Cattaneo, Marco

AU - Lavenu-Bombled, Cécile

AU - Bury, Loredana

AU - Minuz, Pietro

AU - Nurden, Paquita

AU - Cid, Ana R.

AU - Cuker, Adam

AU - Latger-Cannard, Véronique

AU - Favier, Remi

AU - Nichele, Ilaria

AU - Noris, Patrizia

PY - 2015/1/1

Y1 - 2015/1/1

N2 - © 2015 John Wiley & Sons Ltd. This study evaluated 65 pregnancies in 34 women with five different inherited platelet function disorders. Gestation was similar to that of the general population. Severe bleeds requiring blood transfusions were observed in 50% of deliveries in Glanzmann thrombasthenia (GT), but not in the patients with delta storage pool disease, Hermansky-Pudlak syndrome, P2Y12 defect or defect of thromboxane A2 receptor. Of note, severe haemorrhage also occurred in women with GT who had received prophylactic platelet transfusions, suggesting that better preventive treatments are required. Diagnosis and degree of spontaneous bleeding tendency before pregnancy were reliable parameters to predict the delivery-related bleeding risk.

AB - © 2015 John Wiley & Sons Ltd. This study evaluated 65 pregnancies in 34 women with five different inherited platelet function disorders. Gestation was similar to that of the general population. Severe bleeds requiring blood transfusions were observed in 50% of deliveries in Glanzmann thrombasthenia (GT), but not in the patients with delta storage pool disease, Hermansky-Pudlak syndrome, P2Y12 defect or defect of thromboxane A2 receptor. Of note, severe haemorrhage also occurred in women with GT who had received prophylactic platelet transfusions, suggesting that better preventive treatments are required. Diagnosis and degree of spontaneous bleeding tendency before pregnancy were reliable parameters to predict the delivery-related bleeding risk.

KW - Bleeding diathesis

KW - Bleeding risk

KW - Inherited platelet disorders

KW - Perinatal haemostasis

KW - Pregnancy

U2 - 10.1111/bjh.13458

DO - 10.1111/bjh.13458

M3 - Article

SN - 0007-1048

VL - 170

SP - 559

EP - 563

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

Analysis of 65 pregnancies in 34 women with five different forms of inherited platelet function disorders

Abstract

Keywords

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