abused amphetamine derivative. Its effects are psychostimulant (feelings of euphoria/well-being) and sympathomimetic (increase heart rate, blood pressure,
mydriasis). Although METH is usually consumed by
intranasal route (snorting), the number of human studies
evaluating its effects by this route is scarce.
Material and/or methods: An observationalnaturalistic study was conducted to assess the acute pharmacological effects, and oral fluid (saliva) concentrations
of METH. Six healthy experienced drug users (1 female
and 5 males) self-administered a single dose of METH
intranasally (n = 6, 20–30 mg, mean 28 mg) in a closed
recreational setting. Vital signs (blood pressure, heart
rate) were measured at baseline (0 h), 0.5, 1, 1.5, 2, 3 and
4 h after self-administration. Each participant completed
subjective effects questionnaires: A set of Visual Analogue Scales (VAS), the 49-item Addiction Research Centre Inventory (ARCI), and Evaluation of the Subjective
Effects of Substances with Abuse Potential (VESSPASSE). Oral fluid and urine were collected during 4 h and
analysed by LC–MS/MS.
Results: Self-administered METH increased ratings of
euphoria, liking, good and well-being, and increased
blood pressure and heart rate in comparison to baseline.
Concentrations of METH in oral fluid peaked at 1 h and
decreased along the period. The results are like previous
described by oral/intranasal route and other observational studies done by our research group with other
derivatives (MDMA, mephedrone, meyhylone).
Conclusions: METH intranasally produced cardiovascular and euphoric effects typically associated to
psychostimulants drugs. Our results confirm oral fluid is
a useful non-invasive biological matrix to detect METH
|Number of pages||1|
|Journal||Basic & Clinical Pharmacology & Toxicology|
|Issue number||Supl. 2|
|Publication status||Published - May 2022|