An observational study of the acute pharmacological effects of intranasal methamphetamine in humans

Magi Farre Albaladejo, Lourdes Poyatos Blanco, Eulalia Olesti Munoz, Clara Perez Mana, Mireia Ventura Vilamala, Marc Grifell Guardia, Marta Torrens Melich, Rafael De La Torre Fornell, Esther Papaseit Fontanet

Research output: Contribution to journalArticleResearchpeer-review


Objective: Methamphetamine (METH) is the most
abused amphetamine derivative. Its effects are psychostimulant (feelings of euphoria/well-being) and sympathomimetic (increase heart rate, blood pressure,
mydriasis). Although METH is usually consumed by
intranasal route (snorting), the number of human studies
evaluating its effects by this route is scarce.
Material and/or methods: An observationalnaturalistic study was conducted to assess the acute pharmacological effects, and oral fluid (saliva) concentrations
of METH. Six healthy experienced drug users (1 female
and 5 males) self-administered a single dose of METH
intranasally (n = 6, 20–30 mg, mean 28 mg) in a closed
recreational setting. Vital signs (blood pressure, heart
rate) were measured at baseline (0 h), 0.5, 1, 1.5, 2, 3 and
4 h after self-administration. Each participant completed
subjective effects questionnaires: A set of Visual Analogue Scales (VAS), the 49-item Addiction Research Centre Inventory (ARCI), and Evaluation of the Subjective
Effects of Substances with Abuse Potential (VESSPASSE). Oral fluid and urine were collected during 4 h and
analysed by LC–MS/MS.
Results: Self-administered METH increased ratings of
euphoria, liking, good and well-being, and increased
blood pressure and heart rate in comparison to baseline.
Concentrations of METH in oral fluid peaked at 1 h and
decreased along the period. The results are like previous
described by oral/intranasal route and other observational studies done by our research group with other
derivatives (MDMA, mephedrone, meyhylone).
Conclusions: METH intranasally produced cardiovascular and euphoric effects typically associated to
psychostimulants drugs. Our results confirm oral fluid is
a useful non-invasive biological matrix to detect METH
recent use.
Original languageEnglish
Pages (from-to)14-14
Number of pages1
JournalBasic & Clinical Pharmacology & Toxicology
Issue numberSupl. 2
Publication statusPublished - May 2022


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