An iron-based T <inf>1</inf> contrast agent made of iron-phosphate complexes: In vitro and in vivo studies

Elisenda Rodríguez, Rui V. Simoes, Anna Roig, Elies Molins, Nataliya Nedelko, Anna Ślawska-Waniewska, Silvio Aime, Carles Arús, Miquel E. Cabañas, Coral Sanfeliu, Sebastián Cerdán, Maria Luisa García-Martín

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13 Citations (Scopus)

Abstract

A new iron-based T 1 contrast agent consisting of a complex of iron ions coordinated to phosphate and amine ligands (Fe(phos) in short) has been characterized by spectroscopic and magnetic measurements. NMR relaxation studies showed r 1 values to be dependent on the phosphate salt concentration, K2HPO4, present in the medium. r 1 reaches a maximum value of 2.5 mM-1 s-1 for measurements carried out at 7 T and 298 K. 31P MRS, Mössbauer spectroscopy and magnetic measurements of Fe(phos) solutions suggest paramagnetic Fe3+ ions present in the studied iron-phosphate complex. In vitro and in vivo toxicity experiments with C6 cells and CD1 mice, respectively, demonstrated lack of toxicity for Fe(phos) at the highest dose tested in the MRI experiments (12 mM iron for C6 cells and 0.32 mmol iron/kg for mice). Finally, T 1 weighted images of brain tumours in mice have shown positive contrast enhancement of Fe(phos) for tumour afflicted regions in the brain. © 2007 ESMRMB.
Original languageEnglish
Pages (from-to)27-37
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume20
Issue number1
DOIs
Publication statusPublished - 1 Feb 2007

Keywords

  • Fe 8
  • Iron phosphate particles
  • Magnetic resonance imaging
  • T contrast agent 1

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