An Integrative Breakage Model of genome architecture, reshuffling and evolution: The Integrative Breakage Model of genome evolution, a novel multidisciplinary hypothesis for the study of genome plasticity

Marta Farré, Terence J. Robinson, Aurora Ruiz-Herrera

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

© 2015 WILEY Periodicals, Inc. Our understanding of genomic reorganization, the mechanics of genomic transmission to offspring during germ line formation, and how these structural changes contribute to the speciation process, and genetic disease is far from complete. Earlier attempts to understand the mechanism(s) and constraints that govern genome remodeling suffered from being too narrowly focused, and failed to provide a unified and encompassing view of how genomes are organized and regulated inside cells. Here, we propose a new multidisciplinary Integrative Breakage Model for the study of genome evolution. The analysis of the high-level structural organization of genomes (nucleome), together with the functional constrains that accompany genome reshuffling, provide insights into the origin and plasticity of genome organization that may assist with the detection and isolation of therapeutic targets for the treatment of complex human disorders.
Original languageEnglish
Pages (from-to)479-488
JournalBioEssays
Volume37
Issue number5
DOIs
Publication statusPublished - 1 May 2015

Keywords

  • Epigenome
  • Evolution
  • Genome reshuffling
  • Nucleome
  • Recombination
  • Selection

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