An integrated interface for peripheral neural system recording and stimulation: system design, electrical tests and in-vivo results

Caterina Carboni, Lorenzo Bisoni, Nicola Carta, Roberto Puddu, Stanisa Raspopovic, Xavier Navarro, Luigi Raffo, Massimo Barbaro

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

© 2016, Springer Science+Business Media New York. The prototype of an electronic bi-directional interface between the Peripheral Nervous System (PNS) and a neuro-controlled hand prosthesis is presented. The system is composed of 2 integrated circuits: a standard CMOS device for neural recording and a HVCMOS device for neural stimulation. The integrated circuits have been realized in 2 different 0.35μm CMOS processes available from ams. The complete system incorporates 8 channels each including the analog front-end, the A/D conversion, based on a sigma delta architecture and a programmable stimulation module implemented as a 5-bit current DAC; two voltage boosters supply the output stimulation stage with a programmable voltage scalable up to 17V. Successful in-vivo experiments with rats having a TIME electrode implanted in the sciatic nerve were carried out, showing the capability of recording neural signals in the tens of microvolts, with a global noise of 7μVrms, and to selectively elicit the tibial and plantar muscles using different active sites of the electrode.
Original languageEnglish
Article number35
JournalBiomedical Microdevices
Volume18
Issue number2
DOIs
Publication statusPublished - 1 Apr 2016

Keywords

  • Bioelectronic devices
  • Multi-channel neural recording
  • Neural stimulation

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