An exploratory association study of the influence of noradrenergic genes and childhood trauma in Borderline Personality Disorder

Ana Martín-Blanco; Marc Ferrer; Joaquim Soler; Maria Jesús Arranz; Daniel Vega; Joana Bauzà; Natalia Calvo; Matilde Elices; Cristina Sanchez-Mora; Iris García-Martinez; Juliana Salazar; Marta Ribases; Cristina Carmona; Mónica Prat; Juan C. Pascual

doi:10.1016/j.psychres.2015.07.046

An exploratory association study of the influence of noradrenergic genes and childhood trauma in Borderline Personality Disorder

Ana Martín-Blanco, Marc Ferrer, Joaquim Soler, Maria Jesús Arranz, Daniel Vega, Joana Bauzà, Natalia Calvo, Matilde Elices, Cristina Sanchez-Mora, Iris García-Martinez, Juliana Salazar, Marta Ribases, Cristina Carmona, Mónica Prat, Juan C. Pascual

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

© 2015 Elsevier Ireland Ltd. This study investigated the possible association of 40 polymorphisms within 4 noradrenergic genes with BPD risk and the modulating effect of childhood trauma on these associations in 481 BPD subjects and 442 controls. COMT rs5993882, DBH rs77905 and SLC6A2 rs1814270 showed associations with BPD, which were modulated by childhood trauma. However, none of these findings survived Bonferroni correction. Further investigation is needed to clarify the involvement of these genes in BPD pathogenesis.

Original language	English
Pages (from-to)	589-592
Journal	Psychiatry Research
Volume	229
Issue number	1-2
DOIs	https://doi.org/10.1016/j.psychres.2015.07.046
Publication status	Published - 30 Sep 2015

Keywords

Borderline Personality Disorder
Childhood trauma
Noradrenergic system

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Martín-Blanco, A., Ferrer, M., Soler, J., Arranz, M. J., Vega, D., Bauzà, J., Calvo, N., Elices, M., Sanchez-Mora, C., García-Martinez, I., Salazar, J., Ribases, M., Carmona, C., Prat, M., & Pascual, J. C. (2015). An exploratory association study of the influence of noradrenergic genes and childhood trauma in Borderline Personality Disorder. Psychiatry Research, 229(1-2), 589-592. https://doi.org/10.1016/j.psychres.2015.07.046

Martín-Blanco, Ana ; Ferrer, Marc ; Soler, Joaquim ; Arranz, Maria Jesús ; Vega, Daniel ; Bauzà, Joana ; Calvo, Natalia ; Elices, Matilde ; Sanchez-Mora, Cristina ; García-Martinez, Iris ; Salazar, Juliana ; Ribases, Marta ; Carmona, Cristina ; Prat, Mónica ; Pascual, Juan C. / An exploratory association study of the influence of noradrenergic genes and childhood trauma in Borderline Personality Disorder. In: Psychiatry Research. 2015 ; Vol. 229, No. 1-2. pp. 589-592.

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abstract = "{\textcopyright} 2015 Elsevier Ireland Ltd. This study investigated the possible association of 40 polymorphisms within 4 noradrenergic genes with BPD risk and the modulating effect of childhood trauma on these associations in 481 BPD subjects and 442 controls. COMT rs5993882, DBH rs77905 and SLC6A2 rs1814270 showed associations with BPD, which were modulated by childhood trauma. However, none of these findings survived Bonferroni correction. Further investigation is needed to clarify the involvement of these genes in BPD pathogenesis.",

keywords = "Borderline Personality Disorder, Childhood trauma, Noradrenergic system",

author = "Ana Mart{\'i}n-Blanco and Marc Ferrer and Joaquim Soler and Arranz, {Maria Jes{\'u}s} and Daniel Vega and Joana Bauz{\`a} and Natalia Calvo and Matilde Elices and Cristina Sanchez-Mora and Iris Garc{\'i}a-Martinez and Juliana Salazar and Marta Ribases and Cristina Carmona and M{\'o}nica Prat and Pascual, {Juan C.}",

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doi = "10.1016/j.psychres.2015.07.046",

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Martín-Blanco, A, Ferrer, M, Soler, J, Arranz, MJ, Vega, D, Bauzà, J, Calvo, N, Elices, M, Sanchez-Mora, C, García-Martinez, I, Salazar, J, Ribases, M, Carmona, C, Prat, M & Pascual, JC 2015, 'An exploratory association study of the influence of noradrenergic genes and childhood trauma in Borderline Personality Disorder', Psychiatry Research, vol. 229, no. 1-2, pp. 589-592. https://doi.org/10.1016/j.psychres.2015.07.046

An exploratory association study of the influence of noradrenergic genes and childhood trauma in Borderline Personality Disorder. / Martín-Blanco, Ana; Ferrer, Marc; Soler, Joaquim; Arranz, Maria Jesús; Vega, Daniel; Bauzà, Joana; Calvo, Natalia; Elices, Matilde; Sanchez-Mora, Cristina; García-Martinez, Iris; Salazar, Juliana; Ribases, Marta; Carmona, Cristina; Prat, Mónica; Pascual, Juan C.

In: Psychiatry Research, Vol. 229, No. 1-2, 30.09.2015, p. 589-592.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

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AU - Martín-Blanco, Ana

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AU - Soler, Joaquim

AU - Arranz, Maria Jesús

AU - Vega, Daniel

AU - Bauzà, Joana

AU - Calvo, Natalia

AU - Elices, Matilde

AU - Sanchez-Mora, Cristina

AU - García-Martinez, Iris

AU - Salazar, Juliana

AU - Ribases, Marta

AU - Carmona, Cristina

AU - Prat, Mónica

AU - Pascual, Juan C.

PY - 2015/9/30

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N2 - © 2015 Elsevier Ireland Ltd. This study investigated the possible association of 40 polymorphisms within 4 noradrenergic genes with BPD risk and the modulating effect of childhood trauma on these associations in 481 BPD subjects and 442 controls. COMT rs5993882, DBH rs77905 and SLC6A2 rs1814270 showed associations with BPD, which were modulated by childhood trauma. However, none of these findings survived Bonferroni correction. Further investigation is needed to clarify the involvement of these genes in BPD pathogenesis.

AB - © 2015 Elsevier Ireland Ltd. This study investigated the possible association of 40 polymorphisms within 4 noradrenergic genes with BPD risk and the modulating effect of childhood trauma on these associations in 481 BPD subjects and 442 controls. COMT rs5993882, DBH rs77905 and SLC6A2 rs1814270 showed associations with BPD, which were modulated by childhood trauma. However, none of these findings survived Bonferroni correction. Further investigation is needed to clarify the involvement of these genes in BPD pathogenesis.

KW - Borderline Personality Disorder

KW - Childhood trauma

KW - Noradrenergic system

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