TY - JOUR
T1 - An exploratory association study of the influence of noradrenergic genes and childhood trauma in Borderline Personality Disorder
AU - Martín-Blanco, Ana
AU - Ferrer, Marc
AU - Soler, Joaquim
AU - Arranz, Maria Jesús
AU - Vega, Daniel
AU - Bauzà, Joana
AU - Calvo, Natalia
AU - Elices, Matilde
AU - Sanchez-Mora, Cristina
AU - García-Martinez, Iris
AU - Salazar, Juliana
AU - Ribases, Marta
AU - Carmona, Cristina
AU - Prat, Mónica
AU - Pascual, Juan C.
PY - 2015/9/30
Y1 - 2015/9/30
N2 - © 2015 Elsevier Ireland Ltd. This study investigated the possible association of 40 polymorphisms within 4 noradrenergic genes with BPD risk and the modulating effect of childhood trauma on these associations in 481 BPD subjects and 442 controls. COMT rs5993882, DBH rs77905 and SLC6A2 rs1814270 showed associations with BPD, which were modulated by childhood trauma. However, none of these findings survived Bonferroni correction. Further investigation is needed to clarify the involvement of these genes in BPD pathogenesis.
AB - © 2015 Elsevier Ireland Ltd. This study investigated the possible association of 40 polymorphisms within 4 noradrenergic genes with BPD risk and the modulating effect of childhood trauma on these associations in 481 BPD subjects and 442 controls. COMT rs5993882, DBH rs77905 and SLC6A2 rs1814270 showed associations with BPD, which were modulated by childhood trauma. However, none of these findings survived Bonferroni correction. Further investigation is needed to clarify the involvement of these genes in BPD pathogenesis.
KW - Borderline Personality Disorder
KW - Childhood trauma
KW - Noradrenergic system
U2 - 10.1016/j.psychres.2015.07.046
DO - 10.1016/j.psychres.2015.07.046
M3 - Article
VL - 229
SP - 589
EP - 592
IS - 1-2
ER -