An efficient protocol for the enantioselective preparation of a key polyfunctionalized cyclohexane. New access to (R)- and (S)-4-hydroxy-2- cyclohexenone and (R)- and (S)-trans-cyclohex-2-ene-1,4-diol

Pau Bayón, Georgina Marjanet, Gladis Toribio, Ramon Alibés, Pere De March, Marta Figueredo, Josep Font

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

(Chemical Equation Presented) Starting from very accessible raw materials such as p-methoxyphenol, ethylene glycol, and thiophenol, a protocol has been developed to prepare multigram quantities of the polyfunctionalized cyclohexane (±)-7. A highly efficient resolution of (±)-7 has been achieved through enantioselective acetylation catalyzed by Candida antarctica lipase B. Straightforward and enantioselective syntheses of 4-hydroxy-2-cyclohexenone, 1, trans-cyclohex-2-ene-1,4-diol, 2, and their O-protected derivatives 18 and 19 have been readily accomplished from 7. © 2008 American Chemical Society.
Original languageEnglish
Pages (from-to)3486-3491
JournalJournal of Organic Chemistry
Volume73
Issue number9
DOIs
Publication statusPublished - 2 May 2008

Fingerprint Dive into the research topics of 'An efficient protocol for the enantioselective preparation of a key polyfunctionalized cyclohexane. New access to (R)- and (S)-4-hydroxy-2- cyclohexenone and (R)- and (S)-trans-cyclohex-2-ene-1,4-diol'. Together they form a unique fingerprint.

Cite this