An efficient and concise entry to (-)-4,5-dihydroxy-d-threo-l-norvaline. Formal synthesis of clavalanine.

Jesus Ariza, Josep Font, Rosa M. Ortuño

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

The title amino acid (2) has been synthesized for the first time in a seven-step sequence from D-ribonolactone, in 20% overall yield. Since the N-carbamoyl derivative of (2) in its γ-lactone form has been used to prepare clavalanine, a formal total synthesis of this antibiotic is derived. © 1991.
Original languageEnglish
Pages (from-to)1979-1982
JournalTetrahedron Letters
Volume32
Issue number17
DOIs
Publication statusPublished - 22 Apr 1991

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