Abstract
The title amino acid (2) has been synthesized for the first time in a seven-step sequence from D-ribonolactone, in 20% overall yield. Since the N-carbamoyl derivative of (2) in its γ-lactone form has been used to prepare clavalanine, a formal total synthesis of this antibiotic is derived. © 1991.
Original language | English |
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Pages (from-to) | 1979-1982 |
Journal | Tetrahedron Letters |
Volume | 32 |
Issue number | 17 |
DOIs | |
Publication status | Published - 22 Apr 1991 |