An effective enantioselective approach to the securinega alkaloids: Total synthesis of (-)-norsecurinine

Ramón Alibés, Pau Bayón, Pedro De March, Marta Figueredo, Josep Font, Elena García-García, David González-Gálvez

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Abstract

(Chemical Equation Presented) A highly versatile approach to the enantioselective synthesis of securinega alkaloids is presented. Crucial steps are a palladium-catalyzed enantioselective imide alkylation, a vinylogous Mannich reaction, and a ring-closing metathesis process. Through this strategy, the synthesis of (-)-norsecurinine has been accomplished in nine steps and 11% overall yield. © 2005 American Chemical Society.
Original languageEnglish
Pages (from-to)5107-5109
JournalOrganic Letters
Volume7
Issue number22
DOIs
Publication statusPublished - 27 Oct 2005

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