Abstract
(Chemical Equation Presented) A highly versatile approach to the enantioselective synthesis of securinega alkaloids is presented. Crucial steps are a palladium-catalyzed enantioselective imide alkylation, a vinylogous Mannich reaction, and a ring-closing metathesis process. Through this strategy, the synthesis of (-)-norsecurinine has been accomplished in nine steps and 11% overall yield. © 2005 American Chemical Society.
Original language | English |
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Pages (from-to) | 5107-5109 |
Journal | Organic Letters |
Volume | 7 |
Issue number | 22 |
DOIs | |
Publication status | Published - 27 Oct 2005 |