(Chemical Equation Presented) A highly versatile approach to the enantioselective synthesis of securinega alkaloids is presented. Crucial steps are a palladium-catalyzed enantioselective imide alkylation, a vinylogous Mannich reaction, and a ring-closing metathesis process. Through this strategy, the synthesis of (-)-norsecurinine has been accomplished in nine steps and 11% overall yield. © 2005 American Chemical Society.
|Publication status||Published - 27 Oct 2005|
Alibés, R., Bayón, P., De March, P., Figueredo, M., Font, J., García-García, E., & González-Gálvez, D. (2005). An effective enantioselective approach to the securinega alkaloids: Total synthesis of (-)-norsecurinine. Organic Letters, 7(22), 5107-5109. https://doi.org/10.1021/ol0522079