Amyotrophic lateral sclerosis: Current perspectives from basic research to the clinic

Renzo Mancuso, Xavier Navarro

Research output: Contribution to journalReview articleResearchpeer-review

65 Citations (Scopus)


© 2015 Elsevier Ltd. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of upper and lower motoneurons, leading to muscle weakness and paralysis, and finally death. Considerable recent advances have been made in basic research and preclinical therapeutic attempts using experimental models, leading to increasing clinical and translational research in the context of this disease. In this review we aim to summarize the most relevant findings from a variety of aspects about ALS, including evaluation methods, animal models, pathophysiology, and clinical findings, with particular emphasis in understanding the role of every contributing mechanism to the disease for elucidating the causes underlying degeneration of motoneurons and the development of new therapeutic strategies.
Original languageEnglish
Pages (from-to)1-26
JournalProgress in Neurobiology
Publication statusPublished - 1 Oct 2015


  • Amyotrophic lateral sclerosis
  • Motoneurons disease
  • Neurodegeneration
  • Neuromuscular junction
  • Neuroprotection


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