Amperometric thyroxine sensor using a nanocomposite based on graphene modified with gold nanoparticles carrying a thiolated β-cyclodextrin

Jose Muñoz, Marta Riba-Moliner, Lorcan J. Brennan, Yurii K. Gun’ko, Francisco Céspedes, Arántzazu González-Campo, Mireia Baeza

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

© 2016, Springer-Verlag Wien. This article reports a novel electrochemical sensor based on a nanocomposite for the sensitive determination of Thyroxine (T4), the active form of the hormone. Hydrodynamic amperometry is performed with a nanocomposite electrode based on the dispersion of a graphene–based filler hybrid-nanomaterial throughout an insulating epoxy resin in the optimum composition ratio (the near–percolation composition). This hybrid-nanomaterial consists of reduced graphene oxide tuned with gold nanoparticles and a biorecognition agent, the thiolated β-cyclodextrin. Recognition of T4 is accomplished via supramolecular chemistry, due to the formation of an inclusion complex between β-cyclodextrin and T4. The amperometric device operates at +0.85 V vs. Ag/AgCl, where the oxidation of T4 takes place on the electrode surface. The sensor covers the 1.00 nM to 14 nM T4concentration range in a 0.1 M HCl solution, with a detection limit of 1.00 ± 0.02 nM. The sensor can be easily reset by polishing. It exhibits the lowest detection limit regarding to any other electrochemical electrodes for T4 determination previously described in literature. [Figure not available: see fulltext.]
Original languageEnglish
Pages (from-to)1579-1589
JournalMicrochimica Acta
Volume183
Issue number5
DOIs
Publication statusPublished - 1 May 2016

Keywords

  • Biorecognition
  • Carbon filler
  • Epoxy resin
  • High-Resolution Transmission Electron Microscopy
  • Nanocomposite
  • Near-percolation composition

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